Design of a Continuous Tubular Cooling Crystallizer for Process Development on Lab-Scale

被引：61

作者：

Hohmann, Lukas ^{[1
]}

Gorny, Ramona ^{[2
]}

Klaas, Oliver ^{[1
]}

Ahlert, Jonas ^{[1
]}

Wohlgemuth, Kerstin ^{[3
]}

Kockmann, Norbert ^{[1
]}

机构：

[1] TU Dortmund Univ, Dept Biochem & Chem Engn, Lab Equipment Design, Emil Figge Str 68, Dortmund, Germany

[2] TU Dortmund Univ, Dept Biochem & Chem Engn, Lab Solids Proc Engn, Dortmund, Germany

[3] TU Dortmund Univ, Dept Biochem & Chem Engn, Lab Plant & Proc Design, Dortmund, Germany

来源：

CHEMICAL ENGINEERING & TECHNOLOGY | 2016年 / 39卷 / 07期

关键词：

Coiled flow inverter; Continuous cooling crystallization; Product purification; Tubular device; RESIDENCE TIME DISTRIBUTION; SAFETY ASPECTS; HEAT-TRANSFER; COILED FLOW; NUCLEATION; VISCOSITY; PRESSURE; INVERTER; INDUSTRY; BATCH;

D O I：

10.1002/ceat.201600072

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

Continuous manufacturing of fine chemical, life science, and pharmaceutical products is under recent investigation in R&D. As cooling crystallization is an important unit operation for purification of products, continuously operated, scalable devices are required for process development on lab-scale. A tubular crystallizer was developed, based on the coiled flow inverter design. Experimental characterization proved a narrow residence time distribution of the liquid phase close to ideal plug flow. Counter-current air cooling allows for adjusting linear and curved temperature profiles. Unseeded operation with the L-alanine (water) system demonstrated that nucleation has to be actively controlled to successfully apply intensified continuous cooling crystallization processes.

引用

页码：1268 / 1280

页数：13

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