The role of respiratory epithelium in host defence against influenza virus infection

被引：95
作者：
Denney, Laura [1 ]
Ho, Ling-Pei [1 ]
机构：
[1] Univ Oxford, John Radcliffe Hosp, MRC Weatherall Inst Mol Med, MRC Human Immunol Unit, Oxford, England
来源：
BIOMEDICAL JOURNAL | 2018年 / 41卷 / 04期
关键词：
Influenza; Airway epithelium; Defence; Sensing; Injury and repair; SURFACTANT PROTEIN-D; INNATE IMMUNE-RESPONSE; PATTERN-RECOGNITION RECEPTORS; LUNG DENDRITIC CELLS; TOLL-LIKE RECEPTOR-3; DOUBLE-STRANDED-RNA; CD8(+) T-CELLS; A-VIRUS; RIG-I; INTERFERON-LAMBDA;
D O I：
10.1016/j.bj.2018.08.004
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The respiratory epithelium is the major interface between the environment and the host. Sophisticated barrier, sensing, anti-microbial and immune regulatory mechanisms have evolved to help maintain homeostasis and to defend the lung against foreign substances and pathogens. During influenza virus infection, these specialised structural cells and populations of resident immune cells come together to mount the first response to the virus, one which would play a significant role in the immediate and long term outcome of the infection. In this review, we focus on the immune defence machinery of the respiratory epithelium and briefly explore how it repairs and regenerates after infection.
引用
收藏
页码：218 / 233
页数：16
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