The role of respiratory epithelium in host defence against influenza virus infection

被引：95

作者：

Denney, Laura ^{[1
]}

Ho, Ling-Pei ^{[1
]}

机构：

[1] Univ Oxford, John Radcliffe Hosp, MRC Weatherall Inst Mol Med, MRC Human Immunol Unit, Oxford, England

来源：

BIOMEDICAL JOURNAL | 2018年 / 41卷 / 04期

关键词：

Influenza; Airway epithelium; Defence; Sensing; Injury and repair; SURFACTANT PROTEIN-D; INNATE IMMUNE-RESPONSE; PATTERN-RECOGNITION RECEPTORS; LUNG DENDRITIC CELLS; TOLL-LIKE RECEPTOR-3; DOUBLE-STRANDED-RNA; CD8(+) T-CELLS; A-VIRUS; RIG-I; INTERFERON-LAMBDA;

D O I：

10.1016/j.bj.2018.08.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The respiratory epithelium is the major interface between the environment and the host. Sophisticated barrier, sensing, anti-microbial and immune regulatory mechanisms have evolved to help maintain homeostasis and to defend the lung against foreign substances and pathogens. During influenza virus infection, these specialised structural cells and populations of resident immune cells come together to mount the first response to the virus, one which would play a significant role in the immediate and long term outcome of the infection. In this review, we focus on the immune defence machinery of the respiratory epithelium and briefly explore how it repairs and regenerates after infection.

引用

页码：218 / 233

页数：16

共 228 条

[1] The NLRP3 Inflammasome Mediates In Vivo Innate Immunity to Influenza A Virus through Recognition of Viral RNA [J].

Allen, Irving C. ;

Scull, Margaret A. ;

Moore, Chris B. ;

Holl, Eda K. ;

McElvania-TeKippe, Erin ;

Taxman, Debra J. ;

Guthrie, Elizabeth H. ;

Pickles, Raymond J. ;

Ting, Jenny P. -Y. .

IMMUNITY, 2009, 30 (04) :556-565

[2] The novel parainfluenza virus hemagglutinin-neuraminidase inhibitor BCX 2798 prevents lethal synergism between a paramyxovirus and Streptococcus pneumoniae [J].

Alymova, IV ;

Portner, A ;

Takimoto, T ;

Boyd, KL ;

Babu, YS ;

McCullers, JA .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2005, 49 (01) :398-405

[3] Diverse Functions of Pulmonary Collectins in Host Defense of the Lung [J].

Ariki, Shigeru ;

Nishitani, Chiaki ;

Kuroki, Yoshio .

JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY, 2012,

[4] Release of macrophage migration inhibitory factor and CXCL8/interleukin-8 from lung epithelial cells rendered necrotic by influenza A virus infection [J].

Arndt, U ;

Wennemuth, G ;

Barth, P ;

Nain, M ;

Al-Abed, Y ;

Meinhardt, A ;

Gemsa, D ;

Bacher, M .

JOURNAL OF VIROLOGY, 2002, 76 (18) :9298-9306

[5] Mouse type IIFN-producing cells are immature APCs with plasmacytoid morphology [J].

Asselin-Paturel, C ;

Boonstra, A ;

Dalod, M ;

Durand, I ;

Yessaad, N ;

Dezutter-Dambuyant, C ;

Vicari, A ;

O'Garra, A ;

Biron, C ;

Brière, F ;

Trinchieri, G .

NATURE IMMUNOLOGY, 2001, 2 (12) :1144-1150

[6] Keratinocyte growth factor can enhance alveolar epithelial repair by nonmitogenic mechanisms [J].

Atabai, K ;

Ishigaki, M ;

Geiser, T ;

Ueki, I ;

Matthay, MA ;

Ware, LB .

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2002, 283 (01) :L163-L169

[7] An avian influenza H5N1 virus that binds to a human-type receptor [J].

Auewarakul, Prasert ;

Suptawiwat, Ornpreya ;

Kongchanagul, Alita ;

Sangma, Chak ;

Suzuki, Yasuo ;

Ungchusak, Kumnuan ;

Louisirirotchanakul, Suda ;

Lerdsamran, Hatairat ;

Pooruk, Phisanu ;

Thitithanyanont, Arunee ;

Pittayawonganon, Chakrarat ;

Guo, Chao-Tan ;

HiramatSU, Hiroaki ;

Jampangern, Wipawee ;

Chunsutthiwat, Supamit ;

Puthavathanal, Pilaipan .

JOURNAL OF VIROLOGY, 2007, 81 (18) :9950-9955

[8] Ifitm3 Limits the Severity of Acute Influenza in Mice [J].

Bailey, Charles C. ;

Huang, I-Chueh ;

Kam, Christina ;

Farzan, Michael .

PLOS PATHOGENS, 2012, 8 (09)

[9] Influenza A Induces the Major Secreted Airway Mucin MUC5AC in a Protease-EGFR-Extracellular Regulated Kinase-Sp1-Dependent Pathway [J].

Barbier, Diane ;

Garcia-Verdugo, Ignacio ;

Pothlichet, Julien ;

Khazen, Roxana ;

Descamps, Delphyne ;

Rousseau, Karine ;

Thornton, David ;

Si-Tahar, Mustapha ;

Touqui, Lhousseine ;

Chignard, Michel ;

Sallenave, Jean-Michel .

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2012, 47 (02) :149-157

[10] Type 2 alveolar cells are stem cells in adult lung [J].

Barkauskas, Christina E. ;

Cronce, Michael J. ;

Rackley, Craig R. ;

Bowie, Emily J. ;

Keene, Douglas R. ;

Stripp, Barry R. ;

Randell, Scott H. ;

Noble, Paul W. ;

Hogan, Brigid L. M. .

JOURNAL OF CLINICAL INVESTIGATION, 2013, 123 (07) :3025-3036

← 1 2 3 4 5 6 7 8 9 10 →