Copper-Catalyzed Chloro-Arylsulfonylation of Styrene Derivatives via the Insertion of Sulfur Dioxide

被引：19
|
作者：
Li, Yue [1 ,2 ,3 ]
Shen, Lin [1 ,2 ,3 ]
Zhou, Mi [1 ,2 ,3 ]
Xiong, Baojian [1 ,2 ,3 ]
Zhang, Xuemei [1 ,2 ,3 ]
Lian, Zhong [1 ,2 ,3 ]
机构：
[1] Sichuan Univ, Dept Dermatol, State Key Lab Biotherapy, Chengdu 610041, Peoples R China
[2] Sichuan Univ, Canc Ctr, Natl Clin Res Ctr Geriatr, West China Hosp, Chengdu 610041, Peoples R China
[3] Sichuan Univ, West China Sch Pharm, Chengdu 610041, Peoples R China
来源：
ORGANIC LETTERS | 2021年 / 23卷 / 15期
基金：
中国国家自然科学基金;
关键词：
AMINOSULFONYLATION; ALKENES;
D O I：
10.1021/acs.orglett.1c02001
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A copper-catalyzed four-component chloro-arylsulfonylation of styrene derivatives with aryldiazonium tetrafluor-oborates, lithium chloride, and ex-situ generated sulfur dioxide (from SOgen) is presented. This sulfonylation features good functional group compatibility, mild reaction conditions, excellent regioselectivity, and good yields. The robustness and potential of this method have also been successfully demonstrated by a gram-scale reaction. Based on experimental study, a radical-involved mechanism is proposed for the transformation.
引用
收藏
页码：5880 / 5884
页数：5
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