Protective effects of erdosteine, vitamin E, and vitamin C on renal injury induced by the ischemia-reperfusion of the hind limbs in rats

被引：18

作者：

Sirmali, Rana ^{[1
]}

Armagan, Abdullah ^{[2
]}

Oktem, Faruk ^{[3
]}

Uz, Efkan ^{[4
]}

Kirbas, Aynur ^{[4
]}

Donmez, Soner ^{[5
]}

Yilmaz, Haci Ramazan ^{[6
]}

Silay, Mesrur Selcuk ^{[2
]}

Sirmali, Mehmet ^{[7
]}

机构：

[1] Dr Lutfi Kirdar Training & Res Hosp, Dept Biochem, Istanbul, Turkey

[2] Bezmialem Vakif Univ, Dept Urol, Fac Med, Istanbul, Turkey

[3] Bezmialem Vakif Univ, Dept Pediat Nephrol, Fac Med, Istanbul, Turkey

[4] Suleyman Demirel Univ, Dept Biochem, Fac Med, Isparta, Turkey

[5] Nevsehir Univ, Div Biochem, Dept Chem, Nevsehir, Turkey

[6] Mevlana Univ, Dept Med Biol, Fac Med, Konya, Turkey

[7] Univ Alabama Birmingham, Sch Med, Dept Surg, Birmingham, AL 35294 USA

来源：

TURKISH JOURNAL OF MEDICAL SCIENCES | 2015年 / 45卷 / 01期

关键词：

Erdosteine; vitamin E; vitamin C; ischemia-reperfusion; antioxidant enzymes; oxidative stress; kidney; OXIDATIVE STRESS; MODERATE EXERCISE; ANTIOXIDANT; KIDNEY; DAMAGE; LENS; INFLAMMATION; MECHANISMS; MODEL;

D O I：

10.3906/sag-1310-38

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background/aim: To compare the protective efficacy of erdosteine and vitamins C and E against renal injury caused by hind limb ischemia-reperfusion (I/R). Materials and methods: Rats were split into 4 groups: group I as the control, group II as I/R, group III as I/R + erdosteine, and group IV as I/R + vitamins C and E. Superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activities and malondialdehyde (MDA) tissue levels were determined. Results: MDA levels were found comparable with the control group in groups II and III. However, they were considerably decreased in group IV when compared to group II (P < 0.01). Additionally, SOD, CAT, and GSH-Px activities were considerably (P < 0.05) decreased in group II. While CAT and GSH-Px activities were restored (P < 0.01) by vitamin E and C treatment, SOD activity was not significantly affected. While GSH-Px activities were higher (P < 0.05) with erdosteine administration, SOD and CAT activities were unchanged. Conclusion: The protective effect of vitamins C and E is higher than that of erdosteine treatment in reducing the oxidative stress after renal ischemia in this animal model.

引用

页码：33 / 37

页数：5

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