New epigenetic players in stroke pathogenesis: From non-coding RNAs to exosomal non-coding RNAs

被引：38

作者：

Mahjoubin-Tehran, Maryam ^{[1
,2
]}

Rezaei, Samaneh ^{[1
,2
]}

Jesmani, Amin ^{[3
]}

Birang, Nafise ^{[4
]}

Morshedi, Korosh ^{[5
]}

Khanbabaei, Hashem ^{[6
]}

Khan, Haroon ^{[7
]}

Piranviseh, Ashkan ^{[8
]}

Nejati, Majid ^{[9
]}

Aschner, Michael ^{[10
]}

Mirzaei, Hamed ^{[11
]}

机构：

[1] Mashhad Univ Med Sci, Student Res Comm, Mashhad, Razavi Khorasan, Iran

[2] Mashhad Univ Med Sci, Fac Med, Dept Med Biotechnol, Mashhad, Razavi Khorasan, Iran

[3] Univ Tehran Med Sci, Shariati Hosp, Dept Neurosurg, Tehran, Iran

[4] Shiraz Univ Med Sci, Sch Med, Dept Phys Med & Rehabil, Shiraz, Iran

[5] Kashan Univ Med Sci, Sch Med, Kashan, Iran

[6] Kerman Univ Med Sci, Sch Med, Med Phys Dept, Kerman, Iran

[7] Abdul Wali Khan Univ, Dept Pharm, Mardan 23200, Pakistan

[8] Univ Tehran Med Sci, Brain & Spinal Cord Injury Res Ctr, Tehran, Iran

[9] Kashan Univ Med Sci, Anat Sci Res Ctr, Inst Basic Sci, Kashan, Iran

[10] Albert Einstein Coll Med, Dept Mol Pharmacol, Bronx, NY 10463 USA

[11] Kashan Univ Med Sci, Res Ctr Biochem & Nutr Metab Dis, Inst Basic Sci, Kashan, Iran

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2021年 / 140卷

关键词：

Stroke; Long non-coding RNAs; MicroRNAs; Pathogenesis; FOCAL CEREBRAL-ISCHEMIA; BRAIN-BARRIER DISRUPTION; INTRACEREBRAL HEMORRHAGE; OXIDATIVE STRESS; EXTRACELLULAR VESICLES; REPERFUSION INJURY; ENDOTHELIAL-CELLS; NUCLEAR EXPORT; TRANSCRIPTOMIC PROFILES; FUNCTIONAL RECOVERY;

D O I：

10.1016/j.biopha.2021.111753

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Non-coding RNAs (ncRNAs) have critical role in the pathophysiology as well as recovery after ischemic stroke. ncRNAs, particularly microRNAs, and the long non-coding RNAs (lncRNAs) are critical for angiogenesis and neuroprotection, and they have been suggested to be therapeutic, diagnostic and prognostic tools in cerebrovascular diseases, including stroke. Moreover, exosomes have been considered as nanocarriers capable of transferring various cargos, such as lncRNAs and miRNAs to recipient cells, with prominent inter-cellular roles in the mediation of neuro-restorative events following strokes and neural injuries. In this review, we summarize the pathogenic role of ncRNAs and exosomal ncRNAs in the stroke.

引用

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