Fluorination of 2H-Indazoles Using N-Fluorobenzenesulfonimide

被引：13

作者：

Ghosh, Payel ^{[1
]}

Hajra, Alakananda ^{[1
]}

机构：

[1] Visva Bharati, Dept Chem, Santini Ketan 731235, W Bengal, India

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2021年 / 86卷 / 15期

关键词：

ANALOGS; SELECTFLUOR; ACCESS; ESTERS; ACIDS;

D O I：

10.1021/acs.joc.1c01253

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient, simple, and metal-free fluorination of 2H-indazoles has been developed using N-fluorobenzenesulfonimide (NFSI) in water under ambient air. This transformation provides direct access to fluorinated indazole derivatives with broad functionalities in satisfactory yields. The experimental results suggest a radical mechanistic pathway of this protocol.

引用

页码：10883 / 10888

页数：6

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