Intakes of Folate, Vitamin B6, and Vitamin B12 in Relation to All-Cause and Cause-Specific Mortality: A National Population-Based Cohort

被引:23
|
作者
Bo, Yacong [1 ]
Xu, Huadong [2 ]
Zhang, Huanhuan [1 ]
Zhang, Junxi [3 ]
Wan, Zhongxiao [1 ]
Zhao, Xin [4 ]
Yu, Zengli [1 ,3 ]
机构
[1] Zhengzhou Univ, Affiliated Hosp 5, Sch Publ Hlth, Zhengzhou 450000, Peoples R China
[2] Hangzhou Med Coll, Sch Publ Hlth, Hangzhou 310013, Peoples R China
[3] Henan Key Lab Populat Defects Prevent, NHC Key Lab Birth Defects Prevent, Zhengzhou 450000, Peoples R China
[4] Zhengzhou Univ, Affiliated Hosp 3, Zhengzhou 450000, Peoples R China
关键词
diet; folate; vitamin B6; vitamin B12; mortality; ONE-CARBON METABOLISM; CANCER; NUTRIENTS; ALCOHOL; HEALTH; WOMEN;
D O I
10.3390/nu14112253
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
The evidence regarding the intake of dietary folate, vitamin B6, and vitamin B12 in relation to mortality in the general population is limited. This study aimed to examine the relationship between dietary intakes of folate, vitamin B6, and vitamin B12 in relation to all-cause and cause-specific mortality in a large U.S. cohort. This study included a total of 55,569 adults from the Third National Health and Nutrition Examination Survey (NHANES III) and NHANES 1999-2014. Vital data were determined by linking with the National Death Index records through 31 December 2015. Cox proportional hazards models were used to investigate the relationships of all-cause and cause-specific mortality with dietary folate, vitamin B6, and vitamin B12 intake. Dietary intakes of folate and vitamin B6 were inversely associated with mortality from all-cause, cardiovascular disease, and cancer for men and with mortality from all-cause and cardiovascular disease for women. In men, the multivariable hazard ratios (95% confidence intervals) for the highest versus lowest quintiles of folate and vitamin B6 were 0.77 (0.71-0.85) and 0.79 (0.71-0.86) for all-cause mortality, 0.59 (0.48-0.72) and 0.69 (0.56-0.85) for CVD mortality, and 0.68 (0.56-0.84) and 0.73 (0.60-0.90) for cancer mortality, respectively. Among women, the multivariable hazard ratios (95% confidence intervals) for the highest versus lowest quintiles of folate and vitamin B6 were 0.86 (0.78-0.95) and 0.88 (0.80-0.97) for all-cause mortality and 0.53 (0.41-0.69) and 0.56 (0.44-0.73) for CVD mortality, respectively. No significant associations between dietary vitamin B12 and all-cause and cause-specific mortality were observed. In conclusion, higher dietary intakes of folate and vitamin B6 were significantly associated with lower all-cause and cardiovascular mortality. Our findings suggest that increasing the intake of folate and vitamin B6 may lower the mortality risk among U.S. adults.
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页数:11
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