A diversity-oriented, microwave-assisted synthesis of 4-oxo and 4-chloropyrido [2,3d] pyrimidin-7(8H)-ones

被引：11

作者：

Mont, N

Fernández-Megido, L

Teixidó, J

Kappe, CO

Borrell, JI

机构：

[1] Univ Ramon Llull, Inst Quim Sarria, Grp Engn Mol, E-08017 Barcelona, Spain

[2] Karl Franzens Univ Graz, Inst Chem, A-8010 Graz, Austria

来源：

QSAR & COMBINATORIAL SCIENCE | 2004年 / 23卷 / 10期

关键词：

pyrido[2,3-d]pyrimidines; microwave assisted synthesis; combinatorial chemistry; Suzuki coupling;

D O I：

10.1002/qsar.200420033

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A microwave-assisted protocol for the synthesis of 4-oxo and 4-chloropyrido[2,3-d]pyrimidin-7(8H)-ones, 13 and 9 respectively, bearing a carbon substituent at C2 and a chlorine atom at C4 is reported. ne introduction of a wide range of substituents at C2 renders this methodology easily amenable to combinatorial chemistry applications. Two examples of further derivatization of compounds 9, substitution by amine and Suzuki coupling, under microwave irradiation are also described.

引用

页码：836 / 849

页数：14

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