The Determinants of Liver Fibrosis in Patients with Nonalcoholic Fatty Liver Disease and Type 2 Diabetes Mellitus

被引：10

作者：

Dai, Chia-Yen ^{[1
,2
]}

Fang, Tzu-Jung ^{[3
]}

Hung, Wei-Wen ^{[4
]}

Tsai, Hui-Ju ^{[2
,5
,6
]}

Tsai, Yi-Chun ^{[2
,7
,8
,9
,10
]}

机构：

[1] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Hepatobiliary Div, Kaohsiung 807, Taiwan

[2] Kaohsiung Med Univ, Coll Med, Sch Med, Kaohsiung 807, Taiwan

[3] Kaohsiung Med Univ Hosp, Dept Internal Med, Div Geriatr & Gerontol, Kaohsiung 807, Taiwan

[4] Kaohsiung Med Univ Hosp, Div Endocrinol & Metab, Kaohsiung 807, Taiwan

[5] Kaohsiung Med Univ, Kaohsiung Municipal Ta Tung Hosp, Dept Family Med, Kaohsiung 801, Taiwan

[6] Kaohsiung Med Univ, Res Ctr Environm Med, Kaohsiung 807, Taiwan

[7] Kaohsiung Med Univ Hosp, Div Gen Med, Kaohsiung 807, Taiwan

[8] Kaohsiung Med Univ Hosp, Div Nephrol, Kaohsiung 807, Taiwan

[9] Kaohsiung Med Univ, Liquid Biopsy & Cohort Res Ctr, Kaohsiung 807, Taiwan

[10] Kaohsiung Med Univ, Drug Dev & Value Creat Res Ctr, Kaohsiung 807, Taiwan

来源：

BIOMEDICINES | 2022年 / 10卷 / 07期

关键词：

liver fibrosis; type 2 diabetes mellitus; NAFLD; fibroscan; TRANSIENT ELASTOGRAPHY; GLOBAL EPIDEMIOLOGY; PREVALENCE; STEATOHEPATITIS; PATHOGENESIS; MANAGEMENT; STEATOSIS; DIAGNOSIS; STIFFNESS; DELIVERY;

D O I：

10.3390/biomedicines10071487

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Liver fibrosis is a key pathophysiology process in chronic liver disease. It is still unclear whether the impact of liver fibrosis is not fully realized in type 2 diabetes mellitus (T2D) patients with nonalcoholic fatty liver disease (NAFLD), and the factors affecting nonalcoholic steatohepatitis (NASH) or liver stiffness also remain unclear. The aim of this study was to evaluate the determinants of liver fibrosis and in T2D patients with NAFLD. Liver fibrosis and steatosis were measured using transient elastography (FibroScan). Of 226 T2D patients with NAFLD, 50 with liver fibrosis had higher body mass index, serum uric acid, triglyceride and glycated hemoglobin levels and lower high density lipoprotein levels than 176 without liver fibrosis. Multivariate analysis revealed that aging, obesity, sulfonylurea usage and high levels of AST increased the risk of liver fibrosis in T2D patients with NAFLD. Our findings provide useful information to clinical physicians for earlier detection of liver fibrosis in T2D patients with NAFLD and to prevent liver fibrosis through controlling these risk factors.

引用

页数：12

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