Presepsin for the Detection of Late-Onset Sepsis in Preterm Newborns

被引:56
作者
Poggi, Chiara [1 ]
Bianconi, Tommaso [1 ]
Gozzini, Elena [1 ]
Generoso, Marta [1 ]
Dani, Carlo [2 ]
机构
[1] Careggi Univ Hosp Florence, Div Neonatol, Florence, Italy
[2] Careggi Univ Hosp Florence, Dept Neurosci Psychol Drug Res & Child Hlth, Florence, Italy
关键词
SOLUBLE CD14 SUBTYPE; BIRTH-WEIGHT INFANTS; PROCALCITONIN; MORTALITY; INFECTIONS; PREDICTION; DIAGNOSIS;
D O I
10.1542/peds.2014-1755
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
BACKGROUND: Late-onset sepsis (LOS) is among the leading causes of morbidity and mortality in preterm newborns, and currently available diagnostic tools are inadequate. The objective of this study was to evaluate the accuracy of presepsin (P-SEP) as novel biomarker of bacterial infection for the diagnosis of LOS in preterm newborns. METHODS: We prospectively studied newborns <= 32 weeks' gestational age with LOS (n = 19) and noninfected controls (n = 21) at 4 to 60 days' postnatal age. At enrollment, and 1, 3, and 5 days later, we ascertained the C-reactive protein, procalcitonin, and P-SEP in the LOS group, whereas P-SEP alone was ascertained in the control group. RESULTS: P-SEP at enrollment was higher in the LOS than the control group (median 1295 vs 562 ng/L, P = .00001) and remained higher throughout the study period. In the LOS group, P-SEP had a borderline reduction at day 1 versus values at enrollment (median 1011 vs 1295 ng/L, P = .05), whereas C-reactive protein and procalcitonin at day 1 did not differ from baseline values. The receiver operating characteristic curve of P-SEP at enrollment shows an area under the curve of 0.972. The best calculated cutoff value was 885 ng/L, with 94% sensitivity and 100% specificity. Negative likelihood ratio was 0.05, and positive likelihood ratio was infinity. CONCLUSIONS: We demonstrated for the first time in a cohort of preterm newborns that P-SEP is an accurate biomarker for the diagnosis of possible LOS and may also provide useful information for monitoring the response to therapeutic interventions.
引用
收藏
页码:68 / 75
页数:8
相关论文
共 50 条
  • [21] Carboxyhemoglobin Levels in Preterm Neonatal Late-Onset Sepsis: to Predict or not to Predict
    Vardar, Gonca
    Ozek, Eren
    MEDITERRANEAN JOURNAL OF HEMATOLOGY AND INFECTIOUS DISEASES, 2023, 15
  • [22] Early and Late Onset Sepsis in Late Preterm Infants
    Cohen-Wolkowiez, Michael
    Moran, Cassandra
    Benjamin, Daniel K.
    Cotten, C. Michael
    Clark, Reese H.
    Benjamin, Daniel K., Jr.
    Smith, P. Brian
    PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2009, 28 (12) : 1052 - 1056
  • [23] A high burden of late-onset sepsis among newborns admitted to the largest neonatal unit in central Vietnam
    Tran, H. T.
    Doyle, L. W.
    Lee, K. J.
    Dang, N. M.
    Graham, S. M.
    JOURNAL OF PERINATOLOGY, 2015, 35 (10) : 846 - 851
  • [24] Center Variation in Intestinal Microbiota Prior to Late-Onset Sepsis in Preterm Infants
    Taft, Diana H.
    Ambalavanan, Namasivayam
    Schibler, Kurt R.
    Yu, Zhuoteng
    Newburg, David S.
    Deshmukh, Hitesh
    Ward, Doyle V.
    Morrow, Ardythe L.
    PLOS ONE, 2015, 10 (06):
  • [25] Probiotic Supplementation and Late-Onset Sepsis in Preterm Infants: A Meta-analysis
    Rao, Shripada C.
    Athalye-Jape, Gayatri K.
    Deshpande, Girish C.
    Simmer, Karen N.
    Patole, Sanjay K.
    PEDIATRICS, 2016, 137 (03)
  • [26] Pentoxifylline Therapy for Late-Onset Sepsis in Preterm Infants A Randomized Controlled Trial
    Shabaan, Abd Elazeez
    Nasef, Nehad
    Shouman, Basma
    Nour, Islam
    Mesbah, Abeer
    Abdel-Hady, Hesham
    PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2015, 34 (06) : E143 - E148
  • [27] Histologic Chorioamnionitis Is Associated With Reduced Risk of Late-Onset Sepsis in Preterm Infants
    Strunk, Tobias
    Doherty, Dorota
    Jacques, Angela
    Simmer, Karen
    Richmond, Peter
    Kohan, Rolland
    Charles, Adrian
    Burgner, David
    PEDIATRICS, 2012, 129 (01) : E134 - E141
  • [28] Association between birth route and late-onset sepsis in very preterm neonates
    Olivier, F.
    Bertelle, V.
    Shah, P. S.
    Drolet, C.
    Piedboeuf, B.
    JOURNAL OF PERINATOLOGY, 2016, 36 (12) : 1083 - 1087
  • [29] Functional impairments at school age of preterm born children with late-onset sepsis
    van der Ree, Meike
    Tanis, Jozien C.
    Van Braeckel, Koenraad N. J. A.
    Bos, Arend F.
    Roze, Elise
    EARLY HUMAN DEVELOPMENT, 2011, 87 (12) : 821 - 826
  • [30] Late-onset sepsis in newborns caused by Bacillus Cereus: a case report and literature review
    Zhang, Wang
    Ma, Caihua
    Hu, Linghui
    Wang, Ling
    Xu, Falin
    ANNALS OF CLINICAL MICROBIOLOGY AND ANTIMICROBIALS, 2024, 23 (01)