Neutrophil granules: a library of innate immunity proteins

被引：526

作者：

Borregaard, Niels ^{[1
]}

Sorensen, Ole E.

Theilgaard-Wnchl, Kim

机构：

[1] Univ Copenhagen, Dept Hematol, Granulocyte Res Lab, DK-2100 Copenhagen, Denmark

[2] Lund Univ, Dept Clin Res, Div Infect Med, SE-22184 Lund, Sweden

来源：

TRENDS IN IMMUNOLOGY | 2007年 / 28卷 / 08期

关键词：

D O I：

10.1016/j.it.2007.06.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Gene expression profiling has revealed that circulating neutrophils rest between two major bursts of transcriptional and protein synthetic activities. The first occurs in the bone marrow. This equips the neutrophil with stocks of innate defense armory that are packaged into different granule subsets. The second burst occurs when the neutrophil exits circulation and migrates into tissues to find, capture and phagocytose microorganisms. This burst results in the synthesis and secretion of cytokines and chemokines that support resolution of inflammation and healing of damaged tissue. Gene expression profiling has revealed that neutrophils express a variety of innate immunity proteins, known previously only to be expressed in other cells. Likewise, it has become clear that some proteins previously thought to be specific to the neutrophil are expressed in epithelial cells during inflammation.

引用

页码：340 / 345

页数：6

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