Localization of Idd11 is not associated with thymus and NKT cell abnormalities in NOD mice

被引：13

作者：

Brodnicki, TC

Fletcher, AL

Pellicci, DG

Berzins, SP

McClive, P

Quirk, F

Webster, KE

Scott, HS

Boyd, RL

Godfrey, DI

Morahan, G

机构：

[1] Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Genet & Bioinformat Div, Parkville, Vic 3050, Australia

[2] Monash Univ, Monash Immunol & Stem Cell Labs, Clayton, Vic 3168, Australia

[3] Univ Melbourne, Dept Microbiol & Immunol, Parkville, Vic 3052, Australia

[4] Royal Childrens Hosp, Dept Pediat, Parkville, Vic 3052, Australia

[5] Western Australian Inst Med Res, Diabet Res Ctr, Perth, WA, Australia

来源：

DIABETES | 2005年 / 54卷 / 12期

关键词：

D O I：

10.2337/diabetes.54.12.3453

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Congenic mouse strains provide a unique resource for genetic dissection and biological characterization of chromosomal regions associated with diabetes progression in the nonobese diabetic (NOD) mouse. Idd11, a mouse diabetes susceptibility locus, was previously localized to a region on chromosome 4. Comparison of a panel of subcongenic NOD mouse strains with different intervals derived from the nondiabetic C57BL/6 (B6) strain now maps Idd11 to an similar to 8-Mb interval. B6-derived intervals protected congenic NOD mice from diabetes onset, even though lymphocytic infiltration of pancreatic islets was similar to that found in NOD mice. In addition, neither thymic structural irregularities nor NKT cell deficiencies were ameliorated in diabetes-resistant congenic NOD mice, indicating that Idd11 does not contribute to these abnormalities, which do not need to be corrected to prevent disease.

引用

页码：3453 / 3457

页数：5

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