Synthesis of an Intermediate of Nafoxidine via Nickel-Catalyzed Ketone Arylation

被引：6

作者：

Marelli, Enrico ^{[1
]}

Salas, Jose A. Fernandez ^{[1
]}

Nolan, Steven P. ^{[1
,2
]}

机构：

[1] Univ St Andrews, Sch Chem, EaStCHEM, St Andrews KY16 9ST, Fife, Scotland

[2] King Saud Univ, Dept Chem, Coll Sci, Riyadh 11451, Saudi Arabia

来源：

SYNTHESIS-STUTTGART | 2015年 / 47卷 / 14期

基金：

英国工程与自然科学研究理事会;

关键词：

nickel; ketones; arylation; cross coupling; medicinal chemistry; CROSS-COUPLING REACTIONS; N-HETEROCYCLIC CARBENE; ALPHA-ARYLATION; ACYCLIC KETONES; BOND FORMATION; PRE-CATALYST; C-N; PALLADIUM; EFFICIENT; LIGANDS;

D O I：

10.1055/s-0034-1380813

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A nickel-catalyzed methodology for the -arylation of ketones has been applied to the synthesis of an industrially relevant intermediate. The optimization of the reaction shows the important influence of subtle changes in reaction conditions, and leads to an improved procedure employing only a small excess of the substrate and a relatively low catalyst loading.

引用

页码：2032 / 2037

页数：6

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