Vaccination with attenuated simian immunodeficiency virus by DNA inoculation

被引：28
|
作者：
Kent, SJ [1 ]
Dale, CJ
Preiss, S
Mills, J
Campagna, D
Purcell, DFJ
机构：
[1] Univ Melbourne, Dept Microbiol & Immunol, Parkville, Vic 3010, Australia
[2] Macfarlane Burnet Ctr Med Res, Fairfield, Vic 3078, Australia
来源：
JOURNAL OF VIROLOGY | 2001年 / 75卷 / 23期
关键词：
D O I：
10.1128/JVI.75.23.11930-11934.2001
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Delivering attenuated lentivirus vaccines as proviral DNA would be simple and inexpensive. Inoculation of macaques with wild-type simian immunodeficiency virus strain mac239 (SIVmac239) DNA or SIVmac239 DNA containing a single deletion in the 3' nef-long terminal repeat overlap region (nef/LTR) led to sustained SIV infections and AIDS. Injection of SIVmac239 DNA containing identical deletions in both the 5' LTR and 3' nef/LTR resulted in attenuated SIV infections and substantial protection against subsequent mucosal SIVmac251 challenge.
引用
收藏
页码：11930 / 11934
页数：5
相关论文
共 50 条
  • [41] Live, attenuated simian immunodeficiency virus vaccines elicit potent resistance against a challenge with a human immunodeficiency virus type 1 chimeric virus
    Shibata, R
    Siemon, C
    Czajak, SC
    Desrosiers, RC
    Martin, MA
    JOURNAL OF VIROLOGY, 1997, 71 (11) : 8141 - 8148
  • [42] Simian immunodeficiency virus-specific cytotoxic T-lymphocyte induction through DNA vaccination of rhesus monkeys
    Yasutomi, Y
    Robinson, HL
    Lu, S
    Mustafa, F
    Lekutis, C
    Arthos, J
    Mullins, JI
    Voss, G
    Manson, K
    Wyand, M
    Letvin, NL
    JOURNAL OF VIROLOGY, 1996, 70 (01) : 678 - 681
  • [43] INOCULATION OF BABOONS AND MACAQUES WITH SIMIAN IMMUNODEFICIENCY VIRUS MNE, A PRIMATE LENTIVIRUS CLOSELY RELATED TO HUMAN IMMUNODEFICIENCY VIRUS TYPE-2
    BENVENISTE, RE
    MORTON, WR
    CLARK, EA
    TSAI, CC
    OCHS, HD
    WARD, JM
    KULLER, L
    KNOTT, WB
    HILL, RW
    GALE, MJ
    THOULESS, ME
    JOURNAL OF VIROLOGY, 1988, 62 (06) : 2091 - 2101
  • [44] Simian Immunodeficiency Virus Pathogenesis
    Sodora, Donald L.
    Ross, Ted M.
    CURRENT HIV RESEARCH, 2009, 7 (01) : 1 - 1
  • [45] SIMIAN IMMUNODEFICIENCY VIRUS IN PEOPLE
    ESSEX, M
    NEW ENGLAND JOURNAL OF MEDICINE, 1994, 330 (03): : 209 - 210
  • [46] SELECTIVE AMPLIFICATION OF SIMIAN IMMUNODEFICIENCY VIRUS GENOTYPES AFTER INTRARECTAL INOCULATION OF RHESUS-MONKEYS
    TRIVEDI, P
    MEYER, KK
    STREBLOW, DN
    PREUNINGER, BL
    SCHULTZ, KT
    PAUZA, CD
    JOURNAL OF VIROLOGY, 1994, 68 (11) : 7649 - 7653
  • [47] Reversion in vivo after inoculation of a molecular proviral DNA clone of simian immunodeficiency virus with a cytotoxic-T-lymphocyte escape mutation
    Kobayashi, M
    Igarashi, H
    Takeda, A
    Kato, M
    Matano, T
    JOURNAL OF VIROLOGY, 2005, 79 (17) : 11529 - 11532
  • [48] Efficacy of DNA and fowlpox virus priming/boosting vaccines for simian/human immunodeficiency virus
    Dale, CJ
    De Rose, R
    Stratov, I
    Chea, S
    Montefiori, DC
    Thomson, S
    Ramshaw, IA
    Coupar, BEH
    Boyle, DB
    Law, M
    Kent, SJ
    JOURNAL OF VIROLOGY, 2004, 78 (24) : 13819 - 13828
  • [49] Simian immunodeficiency virus promoter exchange results in a highly attenuated strain that protects against uncloned challenge virus
    Blancou, P
    Chenciner, N
    Fang, RHT
    Monceaux, V
    Cumont, MC
    Guétard, D
    Hurtrel, B
    Wain-Hobson, S
    JOURNAL OF VIROLOGY, 2004, 78 (03) : 1080 - 1092
  • [50] Live attenuated, multiply deleted simian immunodeficiency virus causes AIDS in infant and adult macaques
    Baba, TW
    Liska, V
    Khimani, AH
    Ray, NB
    Dailey, PJ
    Penninck, D
    Bronson, R
    Greene, MF
    McClure, HM
    Martin, LN
    Ruprecht, RM
    NATURE MEDICINE, 1999, 5 (02) : 194 - 203
12345