Changes in Biochemical Parameters of the Calcium-Phosphorus Homeostasis in Relation to Nutritional Intake in Very-Low-Birth-Weight Infants

被引：21
作者：
Christmann, Viola [1 ]
Gradussen, Charlotte J. W. [1 ]
Kornmann, Michelle N. [1 ]
Roeleveld, Nel [2 ,3 ]
van Goudoever, Johannes B. [4 ,5 ]
van Heijst, Arno F. J. [1 ]
机构：
[1] Radboud Univ Nijmegen, Med Ctr, Radboudumc Amalia Childrens Hosp, Dept Paediat,Subdiv Neonatol, NL-6500 HB Nijmegen, Netherlands
[2] Radboud Univ Nijmegen, Med Ctr, Radboud Inst Hlth Sci, Dept Hlth Evidence, NL-6500 HB Nijmegen, Netherlands
[3] Radboud Univ Nijmegen, Med Ctr, Radboudumc Amalia Childrens Hosp, Dept Paediat, NL-6500 HB Nijmegen, Netherlands
[4] VU Univ Med Ctr Amsterdam, Dept Paediat, NL-1081 HV Amsterdam, Netherlands
[5] Emma Childrens Hosp AMC Amsterdam, Dept Paediat, NL-1105 AZ Amsterdam, Netherlands
来源：
NUTRIENTS | 2016年 / 8卷 / 12期
关键词：
blood; bone mineralization; minerals; monitoring; nutrition; renal tubular reabsorption; supplementation; urine; METABOLIC BONE-DISEASE; PRETERM INFANTS; ALKALINE-PHOSPHATASE; REFEEDING SYNDROME; NECROTIZING ENTEROCOLITIS; PREMATURE-INFANTS; URINARY-EXCRETION; HUMAN-MILK; GROWTH; OSTEOPENIA;
D O I：
10.3390/nu8120764
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
Preterm infants are at significant risk to develop reduced bone mineralization based on inadequate supply of calcium and phosphorus (Ca-P). Biochemical parameters can be used to evaluate the nutritional intake. The direct effect of nutritional intake on changes in biochemical parameters has not been studied. Our objective was to evaluate the effect of Ca-P supplementation on biochemical markers as serum (s)/urinary (u) Ca and P; alkaline phosphatase (ALP); tubular reabsorption of P (TrP); and urinary ratios for Ca/creatinin (creat) and P/creatinin in Very-Low-Birth-Weight infants on Postnatal Days 1, 3, 5, 7, 10, and 14. This observational study compared two groups with High (n = 30) and Low (n = 40) intake of Ca-P. Birth weight: median (IRQ) 948 (772-1225) vs. 939 (776-1163) grams; and gestational age: 28.2 (26.5-29.6) vs. 27.8 (26.1-29.4) weeks. Daily median concentrations of biochemical parameter were not different between the groups but linear regression mixed model analyses showed that Ca intake increased the uCa and TrP (p = 0.04) and decreased ALP (p = 0.00). Phosphorus intake increased sP, uP and uP/creat ratio and ALP (p <= 0.02) and caused decrease in TrP (p = 0.00). Protein intake decreased sP (p = 0.000), while low gestational age and male gender increased renal excretion of P (p < 0.03). Standardized repeated measurements showed that biochemical parameters were affected by nutritional intake, gestational age and gender.
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页数：17
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