Hepatitis C Virus Infection and Genetic Susceptibility to Therapy

被引：0

作者：

Sibbing, Bernhard ^{[1
]}

Nattermann, Jacob ^{[1
]}

机构：

[1] Univ Hosp Bonn, Dept Internal Med 1, Bonn, Germany

来源：

JOURNAL OF GASTROINTESTINAL AND LIVER DISEASES | 2011年 / 20卷 / 04期

关键词：

HCV; genetic variants; IL28B; therapy; interferon; SINGLE NUCLEOTIDE POLYMORPHISM; SUSTAINED VIROLOGICAL RESPONSE; GENOME-WIDE ASSOCIATION; IL28B GENE; PEGYLATED INTERFERON; PLUS RIBAVIRIN; SPONTANEOUS CLEARANCE; VIRAL CLEARANCE; INTERLEUKIN-28B POLYMORPHISMS; PROMOTER POLYMORPHISM;

D O I：

暂无

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Both response to treatment as well as spontaneous outcome of hepatitis C virus infection is critically affected by host genetic factors. However, most of the identified association genes could not be confirmed in subsequent studies and almost none of the identified risk factors had a noticeable impact on clinical decisions. In contrast, recent land-mark studies identified variations in close proximity to the interleukin 28B gene locus to be independently associated to treatment response and spontaneous viral clearance in hepatitis C genotype 1 infection. These findings and their potential role in future treatment decision-makings will be discussed here.

引用

页码：397 / 406

页数：10

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