Zika Virus IgM Detection and Neutralizing Antibody Profiles 12-19 Months after Illness Onset

被引：40

作者：

Griffin, Isabel ^{[1
]}

Martin, Stacey W. ^{[2
]}

Fischer, Marcs ^{[2
]}

Chambers, Trudy V. ^{[2
]}

Kosoy, Olga ^{[2
]}

Falise, Alyssa ^{[1
]}

Ponomareva, Olga ^{[1
]}

Gillis, Leah D. ^{[3
]}

Blackmore, Carina ^{[4
]}

Jean, Reynald ^{[1
]}

机构：

[1] Florida Dept Hlth Miami Dade Cty, Miami, FL USA

[2] Ctr Dis Control & Prevent, Ft Collins, CO USA

[3] Bur Publ Hlth Labs, Miami, FL USA

[4] Florida Dept Hlth, Tallahassee, FL USA

来源：

EMERGING INFECTIOUS DISEASES | 2019年 / 25卷 / 02期

关键词：

PERSISTENCE; YELLOW; FLORIDA; SERUM;

D O I：

10.3201/eid2502.181286

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Data on the duration of detectable Zika virus-specific IgM in infected persons are limited. Neutralizing antibody cross-reactivity occurs between Zika virus and related flaviviruses, but the degree to which this confounds diagnosis is uncertain. We tested serum specimens collected 12-19 months after illness onset from patients with confirmed Zika virus disease for Zika virus IgM and Zika virus and dengue virus neutralizing antibodies. Among 62 participants, 45 (73%) had detectable Zika virus IgM and 12 (19%) had an equivocal result. Although all patients tested had Zika virus neutralizing antibodies, 39 (63%) also had neutralizing antibodies against dengue virus; of those, 12 (19%) had <4-fold difference between Zika virus and dengue virus titers, and 5 (8%) had dengue virus titer >= 4-fold higher than Zika virus titer. Prolonged detection of IgM and neutralizing antibody cross-reactivity make it difficult to determine the timing of Zika virus infection and differentiate between related flaviviruses.

引用

页码：299 / 303

页数：5

共 23 条

[1]

Bingham AM, 2016, MMWR-MORBID MORTAL W, V65, P475, DOI 10.15585/mmwr.mm6518e2

[2] Virus and antibody dynamics in acute West Nile virus infection [J].