Lehualides A-D, metabolites from a Hawaiian sponge of the genus Plakortis

被引：24

作者：

Sata, N

Abinsay, H

Yoshida, WY

Horgen, FD

Sitachitta, N ^{[1
]}

Kelly, M

Scheuer, PJ

机构：

[1] Univ Hawaii Manoa, Dept Chem, Honolulu, HI 96822 USA

[2] Hawaii Pacific Univ, Coll Nat Sci, Kaneohe, HI 96744 USA

[3] NIWA, Auckland, New Zealand

来源：

JOURNAL OF NATURAL PRODUCTS | 2005年 / 68卷 / 09期

关键词：

D O I：

10.1021/np0500528

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A collection of an undescribed marine sponge of the genus Plakortis yielded four new "polyketide-derived" metabolites, lehualides A-D (1 -4). The structures of compounds 1 -4 were elucidated by interpretation Of spectral data. Compound 2 demonstrated cytotoxicity against an ovarian cancer cell line, while compound 4 was active against both ovarian cancer and leukemia cell lines.

引用

页码：1400 / 1403

页数：4

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