S100A12 in renal and cardiovascular diseases

被引：20

作者：

Nazari, Alireza ^{[1
,2
]}

Khorramdelazad, Hossein ^{[2
,3
]}

Hassanshahi, Gholamhossein ^{[2
,3
]}

Day, Andrew S. ^{[4
]}

Sardoo, Atlas Mashayekhi ^{[5
]}

Fard, Elnaz Tahmooresi ^{[6
]}

Abedinzadeh, Mehdi ^{[7
]}

Nadimi, Ali Esmaeili ^{[8
,9
]}

机构：

[1] Univ Med Sci, Fac Med, Dept Surg, Rafsanjan, Iran

[2] Rafsanjan Univ Med Sci, Fac Med, Mol Med Res Ctr, Rafsanjan, Iran

[3] Univ Med Sci, Dept Immunol, Fac Med, Rafsanjan, Iran

[4] Univ Otago Christchurch, Dept Paediat, Christchurch, New Zealand

[5] Brunel Univ London, Sch Engn & Design & Phys Sci, London, England

[6] Univ Guilan, Dept Biol, Fac Sci, Rasht, Iran

[7] Shahid Sadoughi Univ Med Sci & Hlth Serv, Shahid Rahnemoon Hosp, Dept Urol, Yazd, Iran

[8] Univ Med Sci, Dept Cardiol, Fac Med, Rafsanjan, Iran

[9] Rafsanjan Univ Med Sci, Fac Med, Non Communicable Dis Res Ctr, Rafsanjan, Iran

来源：

LIFE SCIENCES | 2017年 / 191卷

关键词：

S100A12; Receptor for advanced glycation end-products; Chronic kidney disease; Atherosclerosis; Cardiovascular disease; GLYCATION END-PRODUCTS; CHRONIC KIDNEY-DISEASE; PERIPHERAL ARTERIAL-DISEASE; SOLUBLE RECEPTOR; BINDING-PROTEIN; PLASMA S100A12; CALGRANULIN-C; PROINFLAMMATORY LIGAND; SERUM-LEVELS; RAGE;

D O I：

10.1016/j.lfs.2017.10.036

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Expression of S100A12, a small calcium-binding protein, by neutrophils and monocytes/macrophages induces proinflammatory responses via ligation with the receptor for advanced glycation end-products (RAGE) and subsequent activation of intracellular signal transduction pathways such as the nuclear factor (NF)-kappa B pathway. Although S100A12 has been demonstrated to be a useful biomarker during inflammatory conditions, its precise role in the pathogenesis of renal and cardiovascular diseases has not been fully understood. Recently, several studies have employed S100A12 transgenic mice to investigate its pathological effects. Further studies using these models are required before we can translate these findings to human diseases such as renal and cardiovascular diseases.

引用

页码：253 / 258

页数：6

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