Effects of abdominal sepsis in the healing of abdominal wall. Experimental study in rats

被引：3

作者：

Brandao, Alexandre Malta ^{[1
]}

da Silva, Naiara Galvao ^{[1
]}

Melo de Oliveira, Marcos Vinicius ^{[1
]}

Alves de Morais, Pedro Henrique ^{[1
]}

Marques e Silva, Silvana ^{[1
]}

de Sousa, Joao Batista ^{[1
]}

Carneiro, Fabiana Pirani ^{[1
]}

机构：

[1] Univ Hosp Brasilia UnB, Expt Surg Lab, Fac Med, Brasilia, DF, Brazil

来源：

ACTA CIRURGICA BRASILEIRA | 2011年 / 26卷

关键词：

Healing; Abdominal Wall; Sepsis; Tensile Strength; Rats; SEPTIC SHOCK;

D O I：

10.1590/S0102-86502011000800008

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

PURPOSE: To evaluate the influence of sepsis in the process of wound healing in the abdominal wall. METHODS: 40 rats divided into two groups of twenty animals: group of study (E) - septic, and the control group (C) - not septic. The two groups were divided into subgroups of 10 to be killed on the third day (n = 10) or seventh (n = 10) postoperative. Sepsis was induced by ligation and puncture of the cecum. We performed also the section and anastomosis in left colon. The synthesis of the abdominal wall was made with 3-0 silk thread. On the day of re-laparotomy, the abdominal wall was removed for analysis of the breaking strength and histopathological analysis. RESULTS: The mean breaking strength was at third day: E group (1.44 +/- 1.22) and C group (0.35 +/- 0.46). At seventh day the mean breaking strength was: E group (13.01 +/- 7.09) and C group (11.66 +/- 7.38). There was statistical difference in tensile strength. E group at third day with control group (p = 0.019). CONCLUSION: The induction of peritoneal sepsis reduced the breaking strength of the abdominal wall on the third day aftersurgery.

引用

页码：38 / 44

页数：7

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