Bis-animals:: efficient tools for bis-macrocycle synthesis

被引：100

作者：

Le Baccon, M

Chuburu, F

Toupet, L

Handel, H

Soibinet, M

Déchamps-Olivier, I

Barbiere, JP

Aplincourt, M

机构：

[1] Univ Bretagne Occidentale, Lab Chim Electrochim Mol & Chim analyt, CNRS, UMR 6521, F-29285 Brest, France

[2] Univ Rennes 1, Grp Mat Condensee & Mat, CNRS, UMR 6626, F-35042 Rennes, France

[3] Univ Reims, Grp Rech Chim Inorgan, F-51687 Reims 2, France

来源：

NEW JOURNAL OF CHEMISTRY | 2001年 / 25卷 / 09期

关键词：

D O I：

10.1039/b103995b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Tetraazamacrocyclic bis-aminals prove to be excellent tools for the synthesis of symmetrical, dissymmetrical or functionalized bis-tetraazamacrocycles. The key feature of the process is the separation of insoluble mono- or bis-quaternary ammonium salts from solution during the course of the alkylation reaction.

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页码：1168 / 1174

页数：7

相关论文

共 33 条

[1] SIR97:: a new tool for crystal structure determination and refinement [J].

Altomare, A ;

Burla, MC ;

Camalli, M ;

Cascarano, GL ;

Giacovazzo, C ;

Guagliardi, A ;

Moliterni, AGG ;

Polidori, G ;

Spagna, R .

JOURNAL OF APPLIED CRYSTALLOGRAPHY, 1999, 32 :115-119

[2] Synthesis of lipophilic paramagnetic contrast agents [J].

Baker, WC ;

Choi, MJ ;

Hill, DC ;

Thompson, JL ;

Petillo, PA .

JOURNAL OF ORGANIC CHEMISTRY, 1999, 64 (08) :2683-2689

[3] GENERAL-ROUTE FOR THE SYNTHESIS OF MONO N-ALKYLATED DERIVATIVES OF TETRAAZAMACROCYCLES [J].

BERNARD, H ;

YAOUANC, JJ ;

CLEMENT, JC ;

ABBAYES, HD ;

HANDEL, H .

TETRAHEDRON LETTERS, 1991, 32 (05) :639-642

[4] THERMODYNAMIC ASPECTS OF THE POLYAZACYCLOALKANE COMPLEXES WITH CATIONS AND ANIONS [J].

BIANCHI, A ;

MICHELONI, M ;

PAOLETTI, P .

COORDINATION CHEMISTRY REVIEWS, 1991, 110 (01) :17-113

[5] CHARACTERIZATION AND APPLICATION OF A NEW DIPROTECTED CYCLAM - A NOVEL 2-STEP SYNTHESIS OF LINKED TETRAAZAMACROCYCLES [J].

BOITREL, B ;

ANDRIOLETTI, B ;

LACHKAR, M ;

GUILARD, R .

TETRAHEDRON LETTERS, 1995, 36 (28) :4995-4998

[6] Expeditious N-monoalkylation of 1,4,7,10-tetraazacyclododecane (cyclen) via formamido protection [J].

Boldrini, V ;

Giovenzana, GB ;

Pagliarin, R ;

Palmisano, G ;

Sisti, M .

TETRAHEDRON LETTERS, 2000, 41 (33) :6527-6530

[7]

Brandes S, 1996, B SOC CHIM FR, V133, P65

[8] Synthesis and structure-activity relationships of phenylenebis(methylene)-linked bis-azamacrocycles that inhibit HIV-1 and HIV-8 replication by antagonism of the chemokine receptor CXCR4 [J].

Bridger, GJ ;

Skerlj, RT ;

Padmanabhan, S ;

Martellucci, SA ;

Henson, GW ;

Struyf, S ;

Witvrouw, M ;

Schols, D ;

De Clercq, E .

JOURNAL OF MEDICINAL CHEMISTRY, 1999, 42 (19) :3971-3981

[9] SYNTHESIS AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF PHENYLENEBIS(METHYLENE)-LINKED BIS-TETRAAZAMACROCYCLES THAT INHIBIT HIV REPLICATION - EFFECTS OF MACROCYCLIC RING SIZE AND SUBSTITUENTS ON THE AROMATIC LINKER [J].

BRIDGER, GJ ;

SKERLJ, RT ;

THORNTON, D ;

PADMANABHAN, S ;

MARTELLUCCI, SA ;

HENSON, GW ;

ABRAMS, MJ ;

YAMAMOTO, N ;

DEVREESE, K ;

PAUWELS, R ;

DECLERCQ, E .

JOURNAL OF MEDICINAL CHEMISTRY, 1995, 38 (02) :366-378

[10] DINICKEL AND DICOPPER COMPLEXES WITH N,N-LINKED BIS(CYCLAM) LIGANDS - AN IDEAL SYSTEM FOR THE INVESTIGATION OF ELECTROSTATIC EFFECTS ON THE REDOX BEHAVIOR OF PAIRS OF METAL-IONS [J].

CIAMPOLINI, M ;

FABBRIZZI, L ;

PEROTTI, A ;

POGGI, A ;

SEGHI, B ;

ZANOBINI, F .

INORGANIC CHEMISTRY, 1987, 26 (21) :3527-3533

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