Rapid, High Resolution Screening of Biomaterial Hydrogelators by μ2Rheology

被引：19
|
作者：
Schultz, Kelly M. [1 ,2 ]
Bayles, Alexandra V. [1 ,2 ]
Baldwin, Aaron D. [3 ,4 ]
Kiick, Kristi L. [3 ,4 ]
Furst, Eric M. [1 ,2 ]
机构：
[1] Univ Delaware, Dept Chem Engn, Newark, DE 19716 USA
[2] Univ Delaware, Ctr Mol & Engn Thermodynam, Newark, DE 19716 USA
[3] Univ Delaware, Dept Mat Sci & Engn, Newark, DE 19716 USA
[4] Univ Delaware, Delaware Biotechnol Inst, Newark, DE 19716 USA
来源：
BIOMACROMOLECULES | 2011年 / 12卷 / 12期
基金：
美国国家科学基金会; 美国国家卫生研究院;
关键词：
MOLECULAR-SIZE DISTRIBUTION; 3-DIMENSIONAL POLYMERS; PEG HYDROGELS; MICRORHEOLOGY; COMPONENTS; RHEOLOGY; GELATION; PEPTIDE; SYSTEM;
D O I：
10.1021/bm201214r
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A combination of sample manipulation and rheological characterization at the microscale is used to identify the gelation of poly(ethylene glycol)-heparin hydrogels over a wide range of compositions. A microfluidic device produces 50-100 droplet samples, each with a different composition. Multiple particle tracking microrheology is used to measure the rheological state of each sample. This combination requires little material and enables efficient and rapid screening of gelation conditions. The high resolution data identifies the gelation reaction percolation boundaries and a lower limit of the total hydrogelator concentration for gelation to occur, which can be used for the subsequent engineering, testing, and processing of these materials.
引用
收藏
页码：4178 / 4182
页数：5
相关论文
共 50 条
  • [1] Rapid rheological screening to identify conditions of biomaterial hydrogelation
    Schultz, Kelly M.
    Baldwin, Aaron D.
    Kiick, Kristi L.
    Furst, Eric M.
    SOFT MATTER, 2009, 5 (04) : 740 - 742
  • [2] Using μ2rheology to quantify rheological properties during repeated reversible phase transitions of soft matter
    Wehrman, Matthew D.
    Milstrey, Melissa J.
    Lindberg, Seth
    Schultz, Kelly M.
    LAB ON A CHIP, 2017, 17 (12) : 2085 - 2094
  • [3] An integrated high resolution mass spectrometric data acquisition method for rapid screening of saponins in Panax notoginseng (Sanqi)
    Lai, Chang-Jiang-Sheng
    Tan, Ting
    Zeng, Su-Ling
    Qi, Lian-Wen
    Liu, Xin-Guang
    Dong, Xin
    Li, Ping
    Liu, E-Hu
    JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2015, 109 : 184 - 191
  • [4] Sea Ice Rheology Experiment (SIREx): 2. Evaluating Linear Kinematic Features in High-Resolution Sea Ice Simulations
    Hutter, Nils
    Bouchat, Amelie
    Dupont, Frederic
    Dukhovskoy, Dmitry
    Koldunov, Nikolay
    Lee, Younjoo J.
    Lemieux, Jean-Francois
    Lique, Camille
    Losch, Martin
    Maslowski, Wieslaw
    Myers, Paul G.
    Olason, Einar
    Rampal, Pierre
    Rasmussen, Till
    Talandier, Claude
    Tremblay, Bruno
    Wang, Qiang
    JOURNAL OF GEOPHYSICAL RESEARCH-OCEANS, 2022, 127 (04)
  • [5] High Pressure Rheology and Viscosity of Monoethanolamine with n-Methyl-2-Pyrrolidone and Water Hybrid Solvent
    Tan, L. S.
    Shariff, A. M.
    Lau, K. K.
    Shaikh, M. S.
    Murshid, G.
    PROCEEDING OF 4TH INTERNATIONAL CONFERENCE ON PROCESS ENGINEERING AND ADVANCED MATERIALS (ICPEAM 2016), 2016, 148 : 5 - 10
  • [6] A Progress Report on the Development of the High-Resolution Rapid Refresh Ensemble
    Kalina, Evan A.
    Jankov, Isidora
    Alcott, Trevor
    Olson, Joseph
    Beck, Jeffrey
    Berner, Judith
    Dowell, David
    Alexander, Curtis
    WEATHER AND FORECASTING, 2021, 36 (03) : 791 - 804
  • [7] Preventive doping control screening analysis of prohibited substances in human urine using rapid-resolution liquid chromatography/high-resolution time-of-flight mass spectrometry
    Vonaparti, A.
    Lyris, E.
    Angelis, Y. S.
    Panderi, I.
    Koupparis, M.
    Tsantili-Kakoulidou, A.
    Peters, R. J. B.
    Nielen, M. W. F.
    Georgakopoulos, C.
    RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 2010, 24 (11) : 1595 - 1609
  • [8] Study of the Effect of Inhibitors Solutions on the Chemical Composition of Waxes by Rheology Tests and High Resolution Mass Spectrometry
    Souza, Lindamara M.
    Silva, Samantha R. C.
    Filgueiras, Paulo R.
    dos Santos, Francine D.
    Vasconcelos, Gessica A.
    Lacerda, Valdemar, Jr.
    Vaz, Boniek G.
    Romao, Wanderson
    JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY, 2020, 31 (04) : 627 - 637
  • [9] The Impact of Bolus Rheology on Physiological Swallowing Parameters Derived by Pharyngeal High-Resolution Manometry Impedance
    Omari, T.
    Ross, A.
    Schar, M.
    Campbell, J.
    Lewis, D. A.
    Robinson, I.
    Farahani, M.
    Cock, C.
    Mossel, B.
    NEUROGASTROENTEROLOGY AND MOTILITY, 2024,
  • [10] A silicon-glass microwell platform for high-resolution imaging and high-content screening with single cell resolution
    Frisk, Thomas Wilhelm
    Khorshidi, Mohammad Ali
    Guldevall, Karolin
    Vanherberghen, Bruno
    Onfelt, Bjorn
    BIOMEDICAL MICRODEVICES, 2011, 13 (04) : 683 - 693
12345