Solubility and Dissolution Enhancement of Dexibuprofen by Inclusion Complexation with Cyclodextrin

The solubility enhancement ability of different methods was compared by using dexibuprofen (DEX) as a model drug. Binary inclusion complexes of DEX were prepared with beta cyclodextrin (beta CD) at weight ratio of 1:1,1:2 and 1:4 by physical trituration (PT), kneading (KN) and solvent evaporation (SE) method. The phase solubility studies illustrated that DEX solubility increased proportionally with an increase in beta CD concentration. The solubility of DEX was significantly higher when complexed with beta CD by KN method. DEX-beta CD complexes were examined critically by using infrared (FTIR), differential scanning calorimetry (DSC), powder X-ray diffraction (XRD) and scanning electron microscopy (SEM). FTIR and XRD did not show any significant difference between DEX-beta CD complexes prepared by PT and KN method. DSC thermograms of DEX-beta CD prepared by KN method were showed a decrease in the intensity of endothermic peak of DEX more than PT method. XRD results indicated that DEX shifted to less crystalline state when complexed with beta CD. In conclusion, beta CD is suitable to increase the solubility of DEX.