Bidirectional association between fibromyalgia and migraine among probands and unaffected non-twin siblings: A nationwide population-based study

被引:1
作者
Lin, Po-Chun [1 ]
Tsai, Shih-Jen [2 ,3 ,4 ]
Chen, Tzeng-Ji [5 ,6 ,7 ]
Bai, Ya-Mei [2 ,3 ,4 ]
Chen, Mu-Hong [2 ,3 ,4 ]
Liang, Chih-Sung [1 ,8 ]
机构
[1] Triserv Gen Hosp, Natl Def Med Ctr, Dept Psychiat, Beitou Branch, Taipei, Taiwan
[2] Taipei Vet Gen Hosp, Dept Psychiat, Taipei, Taiwan
[3] Natl Yang Ming Chiao Tung Univ, Coll Med, Dept Psychiat, Taipei, Taiwan
[4] Natl Yang Ming Chiao Tung Univ, Inst Brain Sci, Taipei, Taiwan
[5] Taipei Vet Gen Hosp, Dept Family Med, Taipei, Taiwan
[6] Natl Yang Ming Chiao Tung Univ, Inst Hosp & Hlth Care Adm, Taipei, Taiwan
[7] Taipei Vet Gen Hosp, Dept Family Med, Hsinchu Branch, Hsinchu, Taiwan
[8] Natl Def Med Ctr, Dept Psychiat, Taipei, Taiwan
关键词
fibromyalgia; migraine; probands; unaffected siblings; GENOME-WIDE ASSOCIATION; CLINICAL-FEATURES; YOUNG-ADULTS; ADOLESCENTS; PREVALENCE; METAANALYSIS; DEPRESSION; RISK;
D O I
10.1111/papr.13160
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
Objective This study explored the bidirectional relationship between fibromyalgia and migraine among probands with either of the two disorders and their unaffected siblings. Background Evidence suggests a bidirectional association between fibromyalgia and migraine in individuals and in twins. However, whether a bidirectional association between fibromyalgia and migraine also occurs among siblings remains unknown. Methods Using the Taiwan National Health Insurance Research Database, we examined the data of 2677 probands with fibromyalgia, 2780 unaffected siblings, and 11,120 matched controls to assess the risk of migraine. In contrast, 1830 probands with migraine, 1936 unaffected siblings, and 7744 matched controls to assess the risk of fibromyalgia. Results Logistic regression analyses demonstrated that patients with fibromyalgia (odds ratio [OR]: 3.69; 95% confidence interval [CI]: 2.87-4.74) and unaffected siblings (OR: 1.51; 95% CI: 1.08-2.10) were more likely to develop migraine than the controls during the follow-up period. Moreover, patients with migraine and unaffected siblings had a 4.86-fold (95% CI: 3.86-6.09) and 1.59-fold (95% CI: 1.18-2.12) increased risk of fibromyalgia than the controls. Conclusion The bidirectional association between fibromyalgia and migraine among probands and unaffected siblings suggests a familial coaggregation of these two conditions. Additional studies are required to investigate the genetic and environmental etiologies for this coaggregation.
引用
收藏
页码:695 / 701
页数:7
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