Autophagy and the cell biology of age-related disease

被引：350

作者：

Leidal, Andrew M. ^{[1
,2
]}

Levine, Beth ^{[3
,4
,5
]}

Debnath, Jayanta ^{[1
,2
]}

机构：

[1] Univ Calif San Francisco, Dept Pathol, San Francisco, CA 94140 USA

[2] Univ Calif San Francisco, Helen Diller Family Comprehens Canc Ctr, San Francisco, CA 94143 USA

[3] Univ Texas Southwestern Med Ctr Dallas, Dept Internal Med, Ctr Autophagy Res, Dallas, TX USA

[4] Univ Texas Southwestern Med Ctr Dallas, Dept Microbiol, Dallas, TX USA

[5] Univ Texas Southwestern Med Ctr Dallas, Howard Hughes Med Inst, Dallas, TX USA

来源：

NATURE CELL BIOLOGY | 2018年 / 20卷 / 12期

关键词：

LIFE-SPAN EXTENSION; ALPHA-SYNUCLEIN; DIETARY RESTRICTION; SENESCENT CELLS; MITOCHONDRIAL DYSFUNCTION; INCREASED SENSITIVITY; ALZHEIMER-DISEASE; INDUCE AUTOPHAGY; MUSCLE AUTOPHAGY; IMPROVES HEALTH;

D O I：

10.1038/s41556-018-0235-8

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Macroautophagy (autophagy) is a conserved lysosomal degradation process essential for cellular homeostasis and adaption to stress. Accumulating evidence indicates that autophagy declines with age and that impaired autophagy predisposes individuals to age-related diseases, whereas interventions that stimulate autophagy often promote longevity. In this Review, we examine how the autophagy pathway restricts cellular damage and degeneration, and the impact of these functions towards tissue health and organismal lifespan.

引用

页码：1338 / 1348

页数：11

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