Progress on the Function and Application of Thymosin β4

被引：47
作者：
Xing, Yuan [1 ,2 ]
Ye, Yumeng [1 ]
Zuo, Hongyan [1 ]
Li, Yang [1 ,3 ]
机构：
[1] Beijing Inst Radiat Med, Dept Expt Pathol, Beijing, Peoples R China
[2] Hebei North Univ, Affiliated Hosp 1, Dept Pharm, Zhangjiakou, Peoples R China
[3] Anhui Med Univ, Acad Life Sci, Hefei, Peoples R China
来源：
FRONTIERS IN ENDOCRINOLOGY | 2021年 / 12卷
关键词：
thymosin beta 4; apoptosis; inflammation; signaling pathway; tissue repair; angiogenesis; ENDOTHELIAL PROGENITOR CELLS; INTEGRIN-LINKED KINASE; SIGNALING PATHWAY; MYOCARDIAL-INFARCTION; GROWTH-FACTOR; DRY EYE; ANGIOGENESIS; PROMOTES; EXPRESSION; APOPTOSIS;
D O I：
10.3389/fendo.2021.767785
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Thymosin beta 4 (T beta 4) is a multifunctional and widely distributed peptide that plays a pivotal role in several physiological and pathological processes in the body, namely, increasing angiogenesis and proliferation and inhibiting apoptosis and inflammation. Moreover, T beta 4 is effectively utilized for several indications in animal experiments or clinical trials, such as myocardial infarction and myocardial ischemia-reperfusion injury, xerophthalmia, liver and renal fibrosis, ulcerative colitis and colon cancer, and skin trauma. Recent studies have reported the potential application of T beta 4 and its underlying mechanisms. The present study reveals the progress regarding functions and applications of T beta 4.
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页数：13
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