Progress on the Function and Application of Thymosin β4

被引：47

作者：

Xing, Yuan ^{[1
,2
]}

Ye, Yumeng ^{[1
]}

Zuo, Hongyan ^{[1
]}

Li, Yang ^{[1
,3
]}

机构：

[1] Beijing Inst Radiat Med, Dept Expt Pathol, Beijing, Peoples R China

[2] Hebei North Univ, Affiliated Hosp 1, Dept Pharm, Zhangjiakou, Peoples R China

[3] Anhui Med Univ, Acad Life Sci, Hefei, Peoples R China

来源：

FRONTIERS IN ENDOCRINOLOGY | 2021年 / 12卷

关键词：

thymosin beta 4; apoptosis; inflammation; signaling pathway; tissue repair; angiogenesis; ENDOTHELIAL PROGENITOR CELLS; INTEGRIN-LINKED KINASE; SIGNALING PATHWAY; MYOCARDIAL-INFARCTION; GROWTH-FACTOR; DRY EYE; ANGIOGENESIS; PROMOTES; EXPRESSION; APOPTOSIS;

D O I：

10.3389/fendo.2021.767785

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Thymosin beta 4 (T beta 4) is a multifunctional and widely distributed peptide that plays a pivotal role in several physiological and pathological processes in the body, namely, increasing angiogenesis and proliferation and inhibiting apoptosis and inflammation. Moreover, T beta 4 is effectively utilized for several indications in animal experiments or clinical trials, such as myocardial infarction and myocardial ischemia-reperfusion injury, xerophthalmia, liver and renal fibrosis, ulcerative colitis and colon cancer, and skin trauma. Recent studies have reported the potential application of T beta 4 and its underlying mechanisms. The present study reveals the progress regarding functions and applications of T beta 4.

引用

页数：13

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