Neuroprotective effects of lipoxygenase inhibitors against ischemic injury in rat hippocampal slice cultures

被引：36

作者：

Arai, K ^{[1
]}

Nishiyama, N ^{[1
]}

Matsuki, N ^{[1
]}

Ikegaya, Y ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Chem Pharmacol Lab, Bunkyo Ku, Tokyo 1130033, Japan

来源：

BRAIN RESEARCH | 2001年 / 904卷 / 01期

关键词：

ischemia; hippocampus; phospholipase A(2); arachidonic acid; lipoxygenase;

D O I：

10.1016/S0006-8993(01)02491-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Using organotypic cultures of rat hippocampal slices, we investigated the possible involvement of arachidonate cascades in neuronal death following ischemic insult. Oxygen/glucose deprivation-induced neuronal damage was efficiently attenuated by various inhibitors of lipoxygenase. whereas cyclooxygenase inhibitors were less effective. Interestingly, 5- and 12-1ipoxygenases are likely to separately mediate ischemic injury in the hippocampus. The present study will provide novel therapeutic targets for the development of neuroprotective agents. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：167 / 172

页数：6

共 22 条

[1] MECHANISM OF ARACHIDONIC-ACID LIBERATION DURING ISCHEMIA IN GERBIL CEREBRAL-CORTEX [J].

ABE, K ;

KOGURE, K ;

YAMAMOTO, H ;

IMAZAWA, M ;

MIYAMOTO, K .

JOURNAL OF NEUROCHEMISTRY, 1987, 48 (02) :503-509

[2] DISTRIBUTION AND CHARACTERIZATION OF CYCLOOXYGENASE IMMUNOREACTIVITY IN THE OVINE BRAIN [J].

BREDER, CD ;

SMITH, WL ;

RAZ, A ;

MASFERRER, J ;

SEIBERT, K ;

NEEDLEMAN, P ;

SAPER, CB .

JOURNAL OF COMPARATIVE NEUROLOGY, 1992, 322 (03) :409-438

[3]

Diemer N H, 1993, Acta Neurochir Suppl (Wien), V57, P94

[4]

HSU CY, 1989, ANN NY ACAD SCI, V559, P282

[5]

Ikegaya Y, 1999, J NEUROSCI, V19, P802

[6] Hormonal control of programmed cell death apoptosis [J].

Kiess, W ;

Gallaher, B .

EUROPEAN JOURNAL OF ENDOCRINOLOGY, 1998, 138 (05) :482-491

[7] Localization of cytosolic phospholipase A2 messenger RNA mainly in neurons in the rat brain [J].

Kishimoto, K ;

Matsumura, K ;

Kataoka, Y ;

Morii, H ;

Watanabe, Y .

NEUROSCIENCE, 1999, 92 (03) :1061-1077

[8] A 12(S)-hydroxyeicosatetraenoic acid receptor interacts with steroid receptor coactivator-1 [J].

Kurahashi, Y ;

Herbertsson, H ;

Söderström, M ;

Rosenfeld, MG ;

Hammarström, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (11) :5779-5783

[9]

Lammers CH, 1996, J NEUROCHEM, V66, P147

[10] Cyclooxygenase 2 inhibitors: discovery, selectivity and the future [J].

Marnett, LJ ;

Kalgutkar, AS .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1999, 20 (11) :465-469

← 1 2 3 →