Cyanuryl peptide nucleic acid: synthesis and DNA complexation properties

被引：18

作者：

Vysabhattar, Raman ^{[1
]}

Ganesh, K. N. ^{[1
,2
]}

机构：

[1] Natl Chem Lab, Div Organ Chem Synth, Pune 411008, Maharashtra, India

[2] Natl Inst Sci Educ & Res, Pune 411008, Maharashtra, India

来源：

TETRAHEDRON LETTERS | 2008年 / 49卷 / 08期

关键词：

PNA; cyanuryl PNA;

D O I：

10.1016/j.tetlet.2007.12.095

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of cyanuryl PNA monomer (CyaPNA) 6 was achieved by direct N-monoalkylation of cyanuric acid with N-(2-Boc-aminoethyl)-N'-(bromoacetyl)glycyl ethyl ester 4. Compound 6 was incorporated as a T-mimic into PNA oligomers and biophysical studies on their triplexes/duplex complexes with complementary DNA oligomers indicated unusual stabilization of PNA:DNA hybrids when the cyanuryl unit was located in the middle of the PNA oligomer. (c) 2008 Elsevier Ltd. All rights reserved.

引用

页码：1314 / 1318

页数：5

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