Exploring the molecular mechanism of azole resistance in Aspergillus fumigatus

被引：30

作者：

Chen, P. ^{[1
]}

Liu, J. ^{[1
]}

Zeng, M. ^{[1
]}

Sang, H. ^{[1
]}

机构：

[1] Jinling Hosp, Dept Dermatol, 305 Zhongshan East Rd, Nanjing 210002, Jiangsu, Peoples R China

来源：

JOURNAL DE MYCOLOGIE MEDICALE | 2020年 / 30卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Pathogenic fungi; Aspergillus fumigatus; Azole resistance; cyp51; mutation; Non-cyp51; ANTIFUNGAL RESISTANCE; TRIAZOLE-RESISTANCE; DRUG-RESISTANCE; CYP51A GENE; SUSCEPTIBILITY; TRANSPORTER; MUTATIONS; TR46/Y121F/T289A; ITRACONAZOLE; POSACONAZOLE;

D O I：

10.1016/j.mycmed.2019.100915

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Aspergillus infections are increasingly recognized as a global health problem because of limited antifungal drugs and occurrence of azole resistance worldwide. More cyp51-mediated and non-cyp51mediated mechanisms of azole resistance have been identified in clinical and laboratory studies in recent years with applications of molecular biotechnology including next-generation sequencing, reverse genetics and so on. In this review, current research on the molecular mechanisms of azole resistance in A. fumigatus were presented and summarized and meanwhile the putative clinical relevance of these findings from bench work were discussed. Important aims are to gain more insight to mechanism of azole resistance and provide some efficient lead for prevention strategy. (C) 2019 Published by Elsevier Masson SAS.

引用

页数：5

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