Polymeric Nanoparticles in Brain Cancer Therapy: A Review of Current Approaches

被引：46

作者：

Caraway, Chad A. ^{[1
]}

Gaitsch, Hallie ^{[1
,2
,3
]}

Wicks, Elizabeth E. ^{[1
,4
]}

Kalluri, Anita ^{[1
]}

Kunadi, Navya ^{[1
]}

Tyler, Betty M. ^{[1
]}

机构：

[1] Johns Hopkins Univ, Dept Neurosurg, Hunterian Neurosurg Res Lab, Sch Med, Baltimore, MD 21205 USA

[2] Univ Cambridge, Wellcome MRC Cambridge Stem Cell Inst, NIH Oxford Cambridge Scholars Program, Cambridge CB2 1TN, England

[3] Univ Cambridge, Dept Clin Neurosci, Cambridge CB2 1TN, England

[4] Univ Mississippi, Sch Med, Med Ctr, Jackson, MS 39216 USA

来源：

POLYMERS | 2022年 / 14卷 / 14期

基金：

美国国家卫生研究院;

关键词：

brain; cancer therapy; drug delivery; glioblastoma multiforme; nanoparticles; polymers; MESENCHYMAL STEM-CELLS; CONVECTION-ENHANCED DELIVERY; PLGA-BASED NANOPARTICLES; DRUG-DELIVERY; FOCUSED ULTRASOUND; POLYALKYLCYANOACRYLATE NANOPARTICLES; PENETRATING NANOPARTICLES; BARRIER DISRUPTION; ALZHEIMER-DISEASE; MALIGNANT GLIOMA;

D O I：

10.3390/polym14142963

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Translation of novel therapies for brain cancer into clinical practice is of the utmost importance as primary brain tumors are responsible for more than 200,000 deaths worldwide each year. While many research efforts have been aimed at improving survival rates over the years, prognosis for patients with glioblastoma and other primary brain tumors remains poor. Safely delivering chemotherapeutic drugs and other anti-cancer compounds across the blood-brain barrier and directly to tumor cells is perhaps the greatest challenge in treating brain cancer. Polymeric nanoparticles (NPs) are powerful, highly tunable carrier systems that may be able to overcome those obstacles. Several studies have shown appropriately-constructed polymeric NPs cross the blood-brain barrier, increase drug bioavailability, reduce systemic toxicity, and selectively target central nervous system cancer cells. While no studies relating to their use in treating brain cancer are in clinical trials, there is mounting preclinical evidence that polymeric NPs could be beneficial for brain tumor therapy. This review includes a variety of polymeric NPs and how their associated composition, surface modifications, and method of delivery impact their capacity to improve brain tumor therapy.

引用

页数：26