Molecular biology of oral cavity squamous cell carcinoma

被引：26

作者：

Hsu, Phillip J. ^{[1
]}

Yan, Kenneth ^{[2
]}

Shi, Hailing ^{[3
,4
]}

Izumchenko, Evgeny ^{[5
]}

Agrawal, Nishant ^{[2
]}

机构：

[1] Univ Chicago, Med Scientist Training Program, Chicago, IL 60637 USA

[2] Univ Chicago Med, Dept Surg, Sect Otolaryngol Head & Neck Surg, Chicago, IL 60637 USA

[3] Univ Chicago, Howard Hughes Med Inst, Dept Chem, Chicago, IL 60637 USA

[4] Univ Chicago, Howard Hughes Med Inst, Inst Biophys Dynam, Chicago, IL 60637 USA

[5] Univ Chicago Med, Dept Med, Sect Hematol Oncol, Chicago, IL 60637 USA

来源：

ORAL ONCOLOGY | 2020年 / 102卷

关键词：

Oral cancer; Oral cavity cancer; Head and neck cancer; Squamous cell carcinoma; Head and neck squamous cell carcinoma; HNSCC; Cancer genetics; Molecular biology of oral cavity squamous cell carcinoma; Immunotherapy; Epigenetics; GROWTH-FACTOR RECEPTOR; EPITHELIAL-MESENCHYMAL TRANSITION; EGFR SIGNALING NETWORK; CYCLIN D1 EXPRESSION; GENE COPY NUMBER; PROMOTER METHYLATION; DNA METHYLATION; E-CADHERIN; IMMUNOHISTOCHEMICAL EXPRESSION; SURGICAL MARGINS;

D O I：

10.1016/j.oraloncology.2019.104552

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Oral cavity squamous cell carcinoma (OCSCC) is a heterogeneous and complex disease that arises due to dysfunction of multiple molecular signaling pathways. Recent advances in high-throughput genetic sequencing technologies coupled with innovative analytical techniques have begun to characterize the molecular determinants driving OCSCC. An understanding of the key molecular signaling networks underlying the initiation and progression of is essential for informing treatment of the disease. In this chapter, we discuss recent findings of key genes altered in OCSCC and potential treatments targeting these genes.

引用

页数：7

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