SIWV tetrapeptide and ROS-responsive prodrug conjugate for advanced glioblastoma therapy

被引：3

作者：

Park, Yoon Kyung ^{[1
]}

Jangili, Paramesh ^{[2
]}

Zi, Soyu ^{[2
]}

Kang, Rae Hyung ^{[3
,4
]}

Kim, Dokyoung ^{[1
,3
,4
,5
,6
,7
]}

Kim, Jong Seung ^{[2
]}

机构：

[1] Kyung Hee Univ, Grad Sch, Dept Biomed Sci, Seoul 02447, South Korea

[2] Korea Univ, Dept Chem, Seoul 02841, South Korea

[3] Kyung Hee Univ, Med Res Ctr Bioreact React Oxygen Species, Seoul 02447, South Korea

[4] Kyung Hee Univ, Biomed Sci Inst, Seoul 02447, South Korea

[5] Kyung Hee Univ, KHU KIST Dept Converging Sci & Technol, Seoul 02447, South Korea

[6] Kyung Hee Univ, Coll Med, Dept Anat & Neurobiol, Seoul 02447, South Korea

[7] Kyung Hee Univ, Ctr Converging Humanities, Seoul 02447, South Korea

来源：

CHEMICAL COMMUNICATIONS | 2022年 / 58卷 / 78期

基金：

新加坡国家研究基金会;

关键词：

Silicon;

D O I：

10.1039/d2cc03777g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new conjugate formulation, SIWV-PB-SN, based on glioblastoma (GBM)-homing SIWV tetrapeptide and an ROS-responsive prodrug is reported. SIWV-PB-SN selectively penetrates the GBM cells and releases anti-GBM drug (SN-38) via ROS-induced linker cleavage. This study presents a new insight for a more advanced therapeutic approach to overcoming GBM.

引用

页码：10941 / 10944

页数：4

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