Stem cells ameliorate EAE via an indoleamine 2,3-dioxygenase (IDO) mechanism

被引：41

作者：

Matysiak, Maniola ^{[3
]}

Stasiolek, Mariusz ^{[3
]}

Orlowski, Wojciech ^{[3
]}

Jurewicz, Anna ^{[3
]}

Janczar, Szymon ^{[3
]}

Raine, Cedric S. ^{[1
,2
]}

Selmaj, Krzysztof ^{[3
]}

机构：

[1] Albert Einstein Coll Med, Dept Pathol Neuropathol, Bronx, NY 10461 USA

[2] Albert Einstein Coll Med, Dept Neurol & Neurosci, Bronx, NY 10461 USA

[3] Med Univ Lodz, Dept Neurol, Lodz, Poland

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2008年 / 193卷 / 1-2期

关键词：

stem cells; experimental autoimmune encephalomyelitis; indoleamine 2,3-dioxygenase; immunomodulation;

D O I：

10.1016/j.jneuroim.2007.07.025

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Syngeneic, pluripotent Lin(-)Scal(+) bone marrow stem cells (SC), transferred to mice with experimental autoimmune encephalomyelitis, a model of multiple sclerosis, enhanced recovery, prevented relapses and promoted myelin repair. SC-treated mice showed elevated interferon-gamma production and induction of indoleamine 2,3 -dioxygenase (IDO) in CD11c(+) dendritic cells (DC). IDO induction was specific since in the presence of IDO-producing CD11c(+) DC, PLP stimulated T cell proliferation was inhibited and the IDO-inhibitor, 1-MT, abrogated the SC effect. Relapse prevention during chronic disease correlated with decreased responsiveness to PLP178-191 and MBP85-99. Thus, pluripotent SC induce IDO in DC leading to inhibition of antigen reactivity and spreading in EAE. (C) 206 Elsevier B.V. All rights reserved.

引用

页码：12 / 23

页数：12

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