Stem cells ameliorate EAE via an indoleamine 2,3-dioxygenase (IDO) mechanism

被引：41
|
作者：
Matysiak, Maniola [3 ]
Stasiolek, Mariusz [3 ]
Orlowski, Wojciech [3 ]
Jurewicz, Anna [3 ]
Janczar, Szymon [3 ]
Raine, Cedric S. [1 ,2 ]
Selmaj, Krzysztof [3 ]
机构：
[1] Albert Einstein Coll Med, Dept Pathol Neuropathol, Bronx, NY 10461 USA
[2] Albert Einstein Coll Med, Dept Neurol & Neurosci, Bronx, NY 10461 USA
[3] Med Univ Lodz, Dept Neurol, Lodz, Poland
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2008年 / 193卷 / 1-2期
关键词：
stem cells; experimental autoimmune encephalomyelitis; indoleamine 2,3-dioxygenase; immunomodulation;
D O I：
10.1016/j.jneuroim.2007.07.025
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Syngeneic, pluripotent Lin(-)Scal(+) bone marrow stem cells (SC), transferred to mice with experimental autoimmune encephalomyelitis, a model of multiple sclerosis, enhanced recovery, prevented relapses and promoted myelin repair. SC-treated mice showed elevated interferon-gamma production and induction of indoleamine 2,3 -dioxygenase (IDO) in CD11c(+) dendritic cells (DC). IDO induction was specific since in the presence of IDO-producing CD11c(+) DC, PLP stimulated T cell proliferation was inhibited and the IDO-inhibitor, 1-MT, abrogated the SC effect. Relapse prevention during chronic disease correlated with decreased responsiveness to PLP178-191 and MBP85-99. Thus, pluripotent SC induce IDO in DC leading to inhibition of antigen reactivity and spreading in EAE. (C) 206 Elsevier B.V. All rights reserved.
引用
收藏
页码：12 / 23
页数：12
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