Integron-encoded GES-type extended-spectrum β-lactamase with increased activity toward aztreonam in Pseudomonas aeruginosa

被引：128

作者：

Poirel, L

Brinas, L

Fortineau, N

Nordmann, P

机构：

[1] Univ Paris 11, Hop Bicetre, Fac Med Paris Sud, Assistance Publ Hop Paris,Serv Bacteriol Virol, F-94275 Le Kremlin Bicetre, France

[2] Univ La Rioja, Area Bioquim & Biol Mol, Logrono 26006, Spain

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2005年 / 49卷 / 08期

关键词：

D O I：

10.1128/AAC.49.8.3593-3597.2005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A Pseudomonas aeruginosa strain expresses an extended-spectrum beta-lactamase, GES-9, which differs from GES-1 by a Gly243Ser substitution, is inhibited by clavulanic acid and imipenem, and hydrolyzes aztreonam. The bla(GES-9) gene was located inside a class 1 integron structure containing two copies of a novel insertion sequence belonging to the IS1111 family.

引用

页码：3593 / 3597

页数：5

共 29 条

[1] A STANDARD NUMBERING SCHEME FOR THE CLASS-A BETA-LACTAMASES [J].

AMBLER, RP ;

COULSON, AFW ;

FRERE, JM ;

GHUYSEN, JM ;

JORIS, B ;

FORSMAN, M ;

LEVESQUE, RC ;

TIRABY, G ;

WALEY, SG .

BIOCHEMICAL JOURNAL, 1991, 276 :269-270

[2] Growing group of extended-spectrum β-lactamases:: The CTX-M enzymes [J].

Bonnet, R .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2004, 48 (01) :1-14

[3] NEW MOBILE GENE CASSETTES CONTAINING AN AMINOGLYCOSIDE RESISTANCE GENE, AACA7, AND A CHLORAMPHENICOL RESISTANCE GENE, CATB3, IN AN INTEGRON IN PBWH301 [J].

BUNNY, KL ;

HALL, RM ;

STOKES, HW .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1995, 39 (03) :686-693

[4] Emergence of the extended-spectrum β-lactamase GES-1 in a Pseudomonas aeruginosa strain from Brazil:: Report from the SENTRY antimicrobial surveillance program [J].

Castanheira, M ;

Mendes, RE ;

Walsh, TR ;

Gales, AC ;

Jones, RN .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2004, 48 (06) :2344-2345

[5] Molecular characterization of a new class 3 integron in Klebsiella pneumoniae [J].

Correia, M ;

Boavida, F ;

Grosso, F ;

Salgado, MJ ;

Lito, LM ;

Cristino, JM ;

Mendo, S ;

Duarte, A .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2003, 47 (09) :2838-2843

[6] Molecular characterization of a novel class 1 integron containing blaGES-1 and a fused product of aac(3)-ib/Aac(6′)-Ib′ gene cassettes in Pseudomonas aeruginosa [J].

Dubois, W ;

Poirel, L ;

Marie, C ;

Arpin, C ;

Nordmann, P ;

Quentin, C .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2002, 46 (03) :638-645

[7] Mercury resistance determinants related to Tn21, Tn1696, and Tn5053 in enterobacteria from the preantibiotic era [J].

Essa, AMM ;

Julian, DJ ;

Kidd, SP ;

Brown, NL ;

Hobman, JL .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2003, 47 (03) :1115-1119

[8] IBC-1, a novel integron-associated class A β-lactamase with extended-spectrum properties produced by an Enterobacter cloacae clinical strain [J].

Giakkoupi, P ;

Tzouvelekis, LS ;

Tsakris, A ;

Loukova, V ;

Sofianou, D ;

Tzelepi, E .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2000, 44 (09) :2247-2253

[9] Nosocomial spread of the integron-located veb-1-like cassette encoding an extended-spectrum β-lactamase in Pseudomonas aeruginosa in Thailand [J].

Girlich, D ;

Naas, T ;

Leelaporn, A ;

Poirel, L ;

Fennewald, M ;

Nordmann, P .

CLINICAL INFECTIOUS DISEASES, 2002, 34 (05) :603-611

[10] FACTORS AFFECTING THE ISOLATION OF CCC DNA FROM STREPTOMYCES-LIVIDANS AND ESCHERICHIA-COLI [J].

KIESER, T .

PLASMID, 1984, 12 (01) :19-36

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