Adaptive response in frogs chronically exposed to low doses of ionizing radiation in the environment

被引：35

作者：

Audette-Stuart, M. ^{[1
]}

Kim, S. B. ^{[1
]}

McMullin, D. ^{[1
]}

Festarini, A. ^{[1
]}

Yankovich, T. L. ^{[1
]}

Carr, J. ^{[1
]}

Mulpuru, S. ^{[1
]}

机构：

[1] Atom Energy Canada Ltd, Chalk River Labs, Environm Technol Branch, Chalk River, ON K0J 1P0, Canada

来源：

JOURNAL OF ENVIRONMENTAL RADIOACTIVITY | 2011年 / 102卷 / 06期

关键词：

Ionizing radiation; Adaptive response; Micronucleus assay; HUMAN-LYMPHOCYTES; RESISTANCE; APOPTOSIS;

D O I：

10.1016/j.jenvrad.2011.03.001

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Using the micronucleus assay, decreased levels of DNA damage were found after high dose ionizing radiation exposure of liver cells taken from frogs inhabiting a natural environment with above-background levels of ionizing radiation, compared to cells taken from frogs inhabiting background areas. The data obtained from a small number of animals suggest that stress present in the above-background environment could induce an adaptive response to ionizing radiation. This study did not reveal harmful effects of exposure to low levels of radioactivity. On the contrary, stress present in the above-background area may serve to enhance cellular defense mechanisms. Crown Copyright (C) 2011 Published by Elsevier Ltd. All rights reserved.

引用

页码：566 / 573

页数：8

共 9 条

[1]

ALMASSY A, 1987, INT J RAD APPL INS A, V38, P241

[2]

Boreham D. R., 1991, YEAST MOL BIOL BIOTE, P294

[3] Heat-induced thermal tolerance and radiation resistance to apoptosis in human lymphocytes [J].

Boreham, DR ;

Dolling, JA ;

Maves, SR ;

Miller, S ;

Morrison, DP ;

Mitchel, REJ .

BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE, 1997, 75 (04) :393-397

[4] Adaptive response to ionizing radiation-induced chromosome aberrations in rabbit lymphocytes: Effect of pre-exposure to zinc, and copper salts [J].

Cai, L ;

Cherian, MG .

MUTATION RESEARCH-GENETIC TOXICOLOGY, 1996, 369 (3-4) :233-241

[5] MODIFICATION OF RADIATION-INDUCED APOPTOSIS IN RADIATION-ADAPTED OR HYPERTHERMIA-ADAPTED HUMAN-LYMPHOCYTES [J].

CREGAN, SP ;

BOREHAM, DR ;

WALKER, PR ;

BROWN, DL ;

MITCHEL, REJ .

BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE, 1994, 72 (11-12) :475-482

[6] HUMN project: detailed description of the scoring criteria for the cytokinesis-block micronucleus assay using isolated human lymphocyte cultures [J].

Fenech, M ;

Chang, WP ;

Kirsch-Volders, M ;

Holland, N ;

Bonassi, S ;

Zeiger, E .

MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, 2003, 534 (1-2) :65-75

[7] Bovine and rabbit lymphocytes conditioned with hydrogen peroxide show an adaptive response to radiation damage [J].

Flores, MJ ;

Pinero, J ;

Ortiz, T ;

Pastor, N ;

Mateos, JC ;

Cortes, F .

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 1996, 372 (01) :9-15

[8]

Kirchmann R., 1979, IAEASM23296, P187

[9] BETA-RADIATION-INDUCED RESISTANCE TO MNNG INITIATION OF PAPILLOMA BUT NOT CARCINOMA FORMATION IN MOUSE SKIN [J].

MITCHEL, REJ ;

GRAGTMANS, NJ ;

MORRISON, DP .

RADIATION RESEARCH, 1990, 121 (02) :180-186

← 1 →