Human germline editing: a historical perspective

被引：4

作者：

Morange, Michel ^{[1
]}

机构：

[1] Ecole Normale Super, Ctr Cavailles, Republ Savoirs, 29 Rue Ulm, F-75230 Paris 05, France

来源：

HISTORY AND PHILOSOPHY OF THE LIFE SCIENCES | 2017年 / 39卷 / 04期

关键词：

CRISPR-Cas9; Eugenics; Genome editing; Germline modification; Somatic gene therapy; ZINC-FINGER NUCLEASES; SITE-SPECIFIC ENDONUCLEASE; DOUBLE-STRAND BREAKS; HOMOLOGOUS RECOMBINATION; MUSCULAR-DYSTROPHY; IMMUNE-SYSTEM; GENE-THERAPY; CRISPR-CAS; DNA; CELLS;

D O I：

10.1007/s40656-017-0161-2

中图分类号：

N09 [自然科学史]; B [哲学、宗教];

学科分类号：

01 ; 0101 ; 010108 ; 060207 ; 060305 ; 0712 ;

摘要：

The development of the genome editing system called CRISPR-Cas9 has opened a huge debate on the possibility of modifying the human germline. But the types of changes that could and/or ought to be made have not been discussed. To cast some light on this debate, I will describe the story of the CRISPR-Cas9 system. Then, I will briefly review the projects for modification of the human species that were discussed by biologists throughout the twentieth century. Lastly, I will show that for plenty of reasons, both scientific and societal, germline modification is no longer a priority for our societies.

引用

页数：10

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