Found in translation of mTOR signaling

被引：12

作者：

Clohessy, John G. ^{[1
,2
]}

Reschke, Markus ^{[1
,2
]}

Pandolfi, Pier Paolo ^{[1
,2
]}

机构：

[1] Harvard Univ, Sch Med, Beth Israel Deaconess Canc Ctr,Dept Med, Beth Israel Deaconess Med Ctr,Canc Genet Program, Boston, MA 02215 USA

[2] Harvard Univ, Sch Med, Beth Israel Deaconess Canc Ctr,Dept Pathol, Beth Israel Deaconess Med Ctr,Canc Genet Program, Boston, MA 02215 USA

来源：

CELL RESEARCH | 2012年 / 22卷 / 09期

关键词：

TUMOR SUPPRESSION; PROSTATE-CANCER; PTEN; PHOSPHORYLATION; TUMORIGENESIS; METASTASIS; INITIATION; GROWTH; MOUSE;

D O I：

10.1038/cr.2012.85

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The mammalian target of rapamycin (mTOR) protein kinase regulates a wide variety of cellular processes, including protein synthesis, yet the downstream translational program under the control of mTOR is poorly understood. Two recent studies by Hsieh et al. and Thoreen et al. now start to address this issue, and uncover a subset of genes translationally regulated by oncogenic mTOR signaling that may contribute to tumorigenesis.

引用

收藏

页码：1315 / 1318

页数：4

相关论文

共 20 条

[1] A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis [J].

Alimonti, Andrea ;

Nardella, Caterina ;

Chen, Zhenbang ;

Clohessy, John G. ;

Carracedo, Arkaitz ;

Trotman, Lloyd C. ;

Cheng, Ke ;

Varmeh, Shohreh ;

Kozma, Sara C. ;

Thomas, George ;

Rosivatz, Erika ;

Woscholski, Rudiger ;

Cognetti, Francesco ;

Scher, Howard I. ;

Pandolfi, Pier Paolo .

JOURNAL OF CLINICAL INVESTIGATION, 2010, 120 (03) :681-693

[2] High-Resolution View of the Yeast Meiotic Program Revealed by Ribosome Profiling [J].

Brar, Gloria A. ;

Yassour, Moran ;

Friedman, Nir ;

Regev, Aviv ;

Ingolia, Nicholas T. ;

Weissman, Jonathan S. .

SCIENCE, 2012, 335 (6068) :552-557

[3] Pten is essential for embryonic development and tumour suppression [J].

Di Cristofano, A ;

Pesce, B ;

Cordon-Cardo, C ;

Pandolfi, PP .

NATURE GENETICS, 1998, 19 (04) :348-355

[4] Pten and p27KIP1 cooperate in prostate cancer tumor suppression in the mouse [J].

Di Cristofano, A ;

De Acetis, M ;

Koff, A ;

Cordon-Cardo, C ;

Pandolfi, PP .

NATURE GENETICS, 2001, 27 (02) :222-224

[5] eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression [J].

Furic, Luc ;

Rong, Liwei ;

Larsson, Ola ;

Koumakpayi, Ismael Herve ;

Yoshida, Kaori ;

Brueschke, Andrea ;

Petroulakis, Emmanuel ;

Robichaud, Nathaniel ;

Pollak, Michael ;

Gaboury, Louis A. ;

Pandolfi, Pier Paolo ;

Saad, Fred ;

Sonenberg, Nahum .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (32) :14134-14139

[6] mTORC1 and mTORC2 Regulate EMT, Motility, and Metastasis of Colorectal Cancer via RhoA and Rac1 Signaling Pathways [J].

Gulhati, Pat ;

Bowen, Kanika A. ;

Liu, Jianyu ;

Stevens, Payton D. ;

Rychahou, Piotr G. ;

Chen, Min ;

Lee, Eun Y. ;

Weiss, Heidi L. ;

O'Connor, Kathleen L. ;

Gao, Tianyan ;

Evers, B. Mark .

CANCER RESEARCH, 2011, 71 (09) :3246-3256

[7] Mammalian microRNAs predominantly act to decrease target mRNA levels [J].

Guo, Huili ;

Ingolia, Nicholas T. ;

Weissman, Jonathan S. ;

Bartel, David P. .

NATURE, 2010, 466 (7308) :835-U66

[8] The translational landscape of mTOR signalling steers cancer initiation and metastasis [J].

Hsieh, Andrew C. ;

Liu, Yi ;

Edlind, Merritt P. ;

Ingolia, Nicholas T. ;

Janes, Matthew R. ;

Sher, Annie ;

Shi, Evan Y. ;

Stumpf, Craig R. ;

Christensen, Carly ;

Bonham, Michael J. ;

Wang, Shunyou ;

Ren, Pingda ;

Martin, Michael ;

Jessen, Katti ;

Feldman, Morris E. ;

Weissman, Jonathan S. ;

Shokat, Kevan M. ;

Rommel, Christian ;

Ruggero, Davide .

NATURE, 2012, 485 (7396) :55-U196

[9] Ribosome Profiling of Mouse Embryonic Stem Cells Reveals the Complexity and Dynamics of Mammalian Proteomes [J].

Ingolia, Nicholas T. ;

Lareau, Liana F. ;

Weissman, Jonathan S. .

CELL, 2011, 147 (04) :789-802

[10] Genome-Wide Analysis in Vivo of Translation with Nucleotide Resolution Using Ribosome Profiling [J].

Ingolia, Nicholas T. ;

Ghaemmaghami, Sina ;

Newman, John R. S. ;

Weissman, Jonathan S. .

SCIENCE, 2009, 324 (5924) :218-223