Mitochondrial cytochrome c biogenesis: no longer an enigma

被引：102

作者：

Babbitt, Shalon E. ^{[1
]}

Sutherland, Molly C. ^{[1
]}

Francisco, Brian San ^{[1
]}

Mendez, Deanna L. ^{[1
]}

Kranz, Robert G. ^{[1
]}

机构：

[1] Washington Univ, Dept Biol, St Louis, MO 63130 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2015年 / 40卷 / 08期

基金：

美国国家卫生研究院;

关键词：

cytochrome c; mitochondria; heme attachment; holocytochrome c synthase; LINEAR SKIN DEFECTS; HEME LYASE ACTIVITY; APOCYTOCHROME-C; SYSTEM-I; SACCHAROMYCES-CEREVISIAE; INTERMEMBRANE SPACE; ELECTRON-TRANSFER; ESCHERICHIA-COLI; MLS SYNDROME; YEAST MITOCHONDRIA;

D O I：

10.1016/j.tibs.2015.05.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cytochromes c (cyt c) and c(1) are heme proteins that are essential for aerobic respiration. Release of cyt c from mitochondria is an important signal in apoptosis initiation. Biogenesis of c-type cytochromes involves covalent attachment of heme to two cysteines (at a conserved CXXCH sequence) in the apocytochrome. Heme attachment is catalyzed in most mitochondria by holocytochrome c synthase (HCCS)., which is also necessary for the import of apocytochrome c (apocyt c). Thus, HCCS affects cellular levels of cyt c, impacting mitochondrial physiology and cell death. Here, we review the mechanisms of HCCS function and the roles of heme and residues in the CXXCH motif. Additionally, we consider concepts emerging within the two prokaryotic cytochrome c biogenesis pathways.

引用

页码：446 / 455

页数：10

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