Taking microRNAs to heart

被引：118

作者：

Callis, Thomas E. ^{[1
]}

Wang, Da-Zhi ^{[1
]}

机构：

[1] Univ N Carolina, Carolina Cardiovasc Biol Ctr, Dept Cell & Dev Biol, Chapel Hill, NC 27599 USA

来源：

TRENDS IN MOLECULAR MEDICINE | 2008年 / 14卷 / 06期

关键词：

D O I：

10.1016/j.molmed.2008.03.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

MicroRNAs (miRNAs) are a class of highly conserved, small non-coding RNAs that regulate gene expression post-transcriptionally. The emerging field of miRNA biology has begun to reveal roles for these regulatory molecules in a wide range of biological processes. Dys-regulated miRNA expression has been correlated to diseased hearts in human patients, whereas inhibiting the maturation of miRNAs conditionally in murine hearts has revealed that miRNAs are essential for cardiac development and function. Moreover, genetic studies have identified distinct roles for specific miRNAs during cardiogenesis, cardiac hypertrophy and electrical conduction. These previously unrecognized relationships shed new light on the regulatory mechanisms underlying heart development and pathology and suggest the potential importance of miRNAs as diagnostic markers and therapeutic targets for cardiovascular disease.

引用

页码：254 / 260

页数：7

共 54 条

[1] The miRNA-processing enzyme dicer is essential for the morphogenesis and maintenance of hair follicles [J].

Andl, Thomas ;

Murchison, Elizabeth P. ;

Liu, Fei ;

Zhang, Yuhang ;

Yunta-Gonzalez, Monica ;

Tobias, John W. ;

Andl, Claudia D. ;

Seykora, John T. ;

Hannon, Gregory J. ;

Millar, Sarah E. .

CURRENT BIOLOGY, 2006, 16 (10) :1041-1049

[2] Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation [J].

Bagga, S ;

Bracht, J ;

Hunter, S ;

Massirer, K ;

Holtz, J ;

Eachus, R ;

Pasquinelli, AE .

CELL, 2005, 122 (04) :553-563

[3] Dicer is essential for mouse development [J].

Bernstein, E ;

Kim, SY ;

Carmell, MA ;

Murchison, EP ;

Alcorn, H ;

Li, MZ ;

Mills, AA ;

Elledge, SJ ;

Anderson, KV ;

Hannon, GJ .

NATURE GENETICS, 2003, 35 (03) :215-217

[4] MicroRNAs regulate the expression of the alternative splicing factor nPTB during muscle development [J].

Boutz, Paul L. ;

Chawla, Geetanjali ;

Stoilov, Peter ;

Black, Douglas L. .

GENES & DEVELOPMENT, 2007, 21 (01) :71-84

[5] MicroRNA-133 controls cardiac hypertrophy [J].

Care, Alessandra ;

Catalucci, Daniele ;

Felicetti, Federica ;

Bonci, Desiree ;

Addario, Antonio ;

Gallo, Paolo ;

Bang, Marie-Louise ;

Segnalini, Patrizia ;

Gu, Yusu ;

Dalton, Nancy D. ;

Elia, Leonardo ;

Latronico, Michael V. G. ;

Hoydal, Morten ;

Autore, Camillo ;

Russo, Matteo A. ;

Dorn, Gerald W., II ;

Ellingsen, Oyvind ;

Ruiz-Lozano, Pilar ;

Peterson, Kirk L. ;

Croce, Carlo M. ;

Peschle, Cesare ;

Condorelli, Gianluigi .

NATURE MEDICINE, 2007, 13 (05) :613-618

[6] MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells [J].

Chan, JA ;

Krichevsky, AM ;

Kosik, KS .

CANCER RESEARCH, 2005, 65 (14) :6029-6033

[7] The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation [J].

Chen, JF ;

Mandel, EM ;

Thomson, JM ;

Wu, QL ;

Callis, TE ;

Hammond, SM ;

Conlon, FL ;

Wang, DZ .

NATURE GENETICS, 2006, 38 (02) :228-233

[8] Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure [J].

Chen, Jian-Fu ;

Murchison, Elizabeth P. ;

Tang, Ruhang ;

Callis, Thomas E. ;

Tatsuguchi, Mariko ;

Deng, Zhongliang ;

Rojas, Mauricio ;

Hammond, Scott M. ;

Schneider, Michael D. ;

Selzman, Craig H. ;

Meissner, Gerhard ;

Patterson, Cam ;

Hannon, Gregory J. ;

Wang, Da-Zhi .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (06) :2111-2116

[9] Antisense inhibition of human miRNAs and indications for an involvement of miRNA in cell growth and apoptosis [J].

Cheng, AM ;

Byrom, MW ;

Shelton, J ;

Ford, LP .

NUCLEIC ACIDS RESEARCH, 2005, 33 (04) :1290-1297

[10] MicroRNAs are aberrantly expressed in hypertrophic heart - Do they play a role in cardiac hypertrophy? [J].

Cheng, Yunhui ;

Ji, Ruirui ;

Yue, Junming ;

Yang, Jian ;

Liu, Xiaojun ;

Chen, He ;

Dean, David B. ;

Zhang, Chunxiang .

AMERICAN JOURNAL OF PATHOLOGY, 2007, 170 (06) :1831-1840

← 1 2 3 4 5 6 →