Intravesical Bacillus Calmette-Guerin Outcomes in Patients With Bladder Cancer and Asymptomatic Bacteriuria

被引:18
作者
Herr, Harry W. [1 ]
机构
[1] Mem Sloan Kettering Canc Ctr, Dept Urol, New York, NY 10021 USA
关键词
urinary bladder neoplasms; mycobacterium bovis; bacteriuria; PROPHYLAXIS; BIOPSY;
D O I
10.1016/j.juro.2011.10.032
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Purpose: The outcome of intravesical bacillus Calmette-Guerin therapy was studied in patients with asymptomatic bacteriuria. Materials and Methods: A total of 243 patients with high risk, nonmuscle invasive bladder cancer received induction intravesical bacillus Calmette-Guerin therapy. Before starting bacillus Calmette-Guerin they submitted voided urine samples for culture and were treated with bacillus Calmette-Guerin regardless of culture results without antibiotics. Patients were followed every 3 months for tumor recurrence or progression up to 2 years. Results: Of the 243 patients 61 (25%) had significant bacteriuria (greater than 10(4) or greater than 10(5) cfu/ml single organism). Febrile urinary tract infection developed in 1 patient (1.6%) and 2 overall (0.8%) after completing induction bacillus Calmette-Guerin therapy. No patients were admitted to the hospital for bacillus Calmette-Guerin or bacterial sepsis. The 2-year recurrence-free survival rate was 71% vs 73% in uninfected patients (p = 0.73). Conclusions: These data suggest that intravesical bacillus Calmette-Guerin is safe in patients who have asymptomatic bacteriuria and the 2-year disease-free intervals are similar to those of uninfected patients. Such strategy facilitates the timely administration of bacillus Calmette-Guerin therapy and avoids the overuse of antibiotics.
引用
收藏
页码:435 / 437
页数:3
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