The C-terminus of p53: the more you learn the less you know

被引：107
作者：
Ahn, J [1 ]
Prives, C [1 ]
机构：
[1] Columbia Univ, Dept Biol Sci, New York, NY 10027 USA
来源：
NATURE STRUCTURAL BIOLOGY | 2001年 / 8卷 / 09期
关键词：
D O I：
10.1038/nsb0901-730
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
NMR analyses of variants of the p53 tumor suppressor protein that either contain or lack the C-terminus reveal that the C-terminus neither interacts with other regions of p53 nor has an impact on the conformation of the rest of the molecule. Nevertheless, the C-terminus is likely to be critical for regulation of p53 function.
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收藏
页码：730 / 732
页数：3
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