Gene expression of type II collagens in chondro-osteophytes in experimental osteoarthritis

被引：39
作者：
Matyas, JR
Sandell, LJ
Adams, ME
机构：
[1] Department of Anatomy, Calgary, Alta. T2N 4N1
来源：
OSTEOARTHRITIS AND CARTILAGE | 1997年 / 5卷 / 02期
关键词：
osteophytes; type II collagen; alternative splicing; in situ hybridization histochemistry;
D O I：
10.1016/S1063-4584(97)80003-9
中图分类号：
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];
学科分类号：
摘要：
The formation of chondro-osteophytes in osteoarthritic joints is a unique example of adult neochondrogenesis that bears some similarities to growth plate elongation and fracture callus formation. This study uses in situ hybridization histochemistry to define the molecular phenotype of cells in active chondro-osteophytes. Chondro-osteophytes are composed of fibrocytes and osteoblasts that express type I procollagen mRNA, mesenchymal prechondrochytes that express type IIA procollagen mRNA, and maturing chondrocytes that express type IIB procollagen mRNA. Based on the spatial pattern of gene expression and cytomorphology, the neochondrogenesis associated with chondro-osteophyte formation closely resembles that of healing fracture callus.
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页码：99 / 105
页数：7
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