New Routes in GPCR/β-Arrestin-Driven Signaling in Cancer Progression and Metastasis
被引:45
作者:
Bagnato, Anna
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机构:
IRCCS Regina Elena Natl Canc Inst, Unit Preclin Models & New Therapeut Agents, Rome, ItalyIRCCS Regina Elena Natl Canc Inst, Unit Preclin Models & New Therapeut Agents, Rome, Italy
Bagnato, Anna
[1
]
Rosano, Laura
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机构:
IRCCS Regina Elena Natl Canc Inst, Unit Preclin Models & New Therapeut Agents, Rome, ItalyIRCCS Regina Elena Natl Canc Inst, Unit Preclin Models & New Therapeut Agents, Rome, Italy
Rosano, Laura
[1
]
机构:
[1] IRCCS Regina Elena Natl Canc Inst, Unit Preclin Models & New Therapeut Agents, Rome, Italy
Tumor cells acquire invasive and metastatic behavior by sensing changes in the localization and activation of signaling pathways, which in turn determine changes in actin cytoskeleton. The core-scaffold machinery associated to beta-arrestin (beta-arr) is a key mechanism of G-protein coupled receptors (GPCR) to achieve spatiotemporal specificity of different signaling complexes driving cancer progression. Within different cellular contexts, the scaffold proteins beta-arr1 or beta-arr2 may now be considered organizers of protein interaction networks involved in tumor development and metastatic dissemination. Studies have uncovered the importance of the beta-arr engagement with a growing number of receptors, signaling molecules, cytoskeleton regulators, epigenetic modifiers, and transcription factors in GPCR-driven tumor promoting pathways. In many of these molecular complexes, beta-arrs might provide a physical link to active dynamic cytoskeleton, permitting cancer cells to adapt and modify the tumor microenvironment to promote the metastatic spread. Given the complexity and the multidirectional beta-arr-driven signaling in cancer cells, therapeutic targeting of specific GPCR/beta-arr molecular mechanisms is an important avenue to explore when considering future new therapeutic options. The focus of this review is to integrate the most recent developments and exciting findings of how highly connected components of beta-arr-guided molecular connections to other pathways allow precise control over multiple signaling pathways in tumor progression, revealing ways of therapeutically targeting the convergent signals in patients.
机构:
Univ Western Ontario, Dept Physiol & Pharmacol, London, ON, CanadaUniv Western Ontario, Dept Physiol & Pharmacol, London, ON, Canada
Alemayehu, Mistre
;
Dragan, Magdalena
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h-index: 0
机构:
Univ Western Ontario, Dept Physiol & Pharmacol, London, ON, CanadaUniv Western Ontario, Dept Physiol & Pharmacol, London, ON, Canada
Dragan, Magdalena
;
Pape, Cynthia
论文数: 0引用数: 0
h-index: 0
机构:
Univ Western Ontario, Dept Physiol & Pharmacol, London, ON, CanadaUniv Western Ontario, Dept Physiol & Pharmacol, London, ON, Canada
Pape, Cynthia
;
Siddiqui, Iram
论文数: 0引用数: 0
h-index: 0
机构:
Univ Western Ontario, Dept Pathol, London, ON, CanadaUniv Western Ontario, Dept Physiol & Pharmacol, London, ON, Canada
Siddiqui, Iram
;
Sacks, David B.
论文数: 0引用数: 0
h-index: 0
机构:
NIH, Dept Lab Med, Bethesda, MD 20892 USAUniv Western Ontario, Dept Physiol & Pharmacol, London, ON, Canada
Sacks, David B.
;
Di Guglielmo, Gianni M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Western Ontario, Dept Physiol & Pharmacol, London, ON, CanadaUniv Western Ontario, Dept Physiol & Pharmacol, London, ON, Canada
Di Guglielmo, Gianni M.
;
Babwah, Andy V.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Western Ontario, Dept Physiol & Pharmacol, London, ON, Canada
Univ Western Ontario, Childrens Hlth Res Inst, London, ON, Canada
Univ Western Ontario, Lawson Hlth Res Inst, London, ON, Canada
Univ Western Ontario, Dept Obstet & Gynecol, London, ON, CanadaUniv Western Ontario, Dept Physiol & Pharmacol, London, ON, Canada
Babwah, Andy V.
;
Bhattacharya, Moshmi
论文数: 0引用数: 0
h-index: 0
机构:
Univ Western Ontario, Dept Physiol & Pharmacol, London, ON, CanadaUniv Western Ontario, Dept Physiol & Pharmacol, London, ON, Canada
机构:
Inst Genom Fonct, CNRS, UMR 5203, F-34000 Montpellier, France
INSERM, U661, F-34000 Montpellier, France
Univ Montpellier I, UMR 5203, F-34000 Montpellier, France
Univ Montpellier 2, UMR 5203, F-34000 Montpellier, FranceInst Genom Fonct, CNRS, UMR 5203, F-34000 Montpellier, France
Bonnans, Caroline
;
Flaceliere, Maud
论文数: 0引用数: 0
h-index: 0
机构:
Inst Genom Fonct, CNRS, UMR 5203, F-34000 Montpellier, France
INSERM, U661, F-34000 Montpellier, France
Univ Montpellier I, UMR 5203, F-34000 Montpellier, France
Univ Montpellier 2, UMR 5203, F-34000 Montpellier, FranceInst Genom Fonct, CNRS, UMR 5203, F-34000 Montpellier, France
Flaceliere, Maud
;
Grillet, Fanny
论文数: 0引用数: 0
h-index: 0
机构:
Inst Genom Fonct, CNRS, UMR 5203, F-34000 Montpellier, France
INSERM, U661, F-34000 Montpellier, France
Univ Montpellier I, UMR 5203, F-34000 Montpellier, France
Univ Montpellier 2, UMR 5203, F-34000 Montpellier, FranceInst Genom Fonct, CNRS, UMR 5203, F-34000 Montpellier, France
Grillet, Fanny
;
Dantec, Christelle
论文数: 0引用数: 0
h-index: 0
机构:
Inst Genom Fonct, CNRS, UMR 5203, F-34000 Montpellier, France
INSERM, U661, F-34000 Montpellier, France
Univ Montpellier I, UMR 5203, F-34000 Montpellier, France
Univ Montpellier 2, UMR 5203, F-34000 Montpellier, France
Montpellier GenomiX, Inst Genom Fonct, F-34000 Montpellier, FranceInst Genom Fonct, CNRS, UMR 5203, F-34000 Montpellier, France
Dantec, Christelle
;
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Desvignes, Jean-Pierre
;
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机构:
Pannequin, Julie
;
Severac, Dany
论文数: 0引用数: 0
h-index: 0
机构:
Inst Genom Fonct, CNRS, UMR 5203, F-34000 Montpellier, France
INSERM, U661, F-34000 Montpellier, France
Univ Montpellier I, UMR 5203, F-34000 Montpellier, France
Univ Montpellier 2, UMR 5203, F-34000 Montpellier, France
Montpellier GenomiX, Inst Genom Fonct, F-34000 Montpellier, FranceInst Genom Fonct, CNRS, UMR 5203, F-34000 Montpellier, France
Severac, Dany
;
Dubois, Emeric
论文数: 0引用数: 0
h-index: 0
机构:
Inst Genom Fonct, CNRS, UMR 5203, F-34000 Montpellier, France
INSERM, U661, F-34000 Montpellier, France
Univ Montpellier I, UMR 5203, F-34000 Montpellier, France
Univ Montpellier 2, UMR 5203, F-34000 Montpellier, France
Montpellier GenomiX, Inst Genom Fonct, F-34000 Montpellier, FranceInst Genom Fonct, CNRS, UMR 5203, F-34000 Montpellier, France
Dubois, Emeric
;
Bibeau, Frederic
论文数: 0引用数: 0
h-index: 0
机构:
Ctr Reg Lutte Canc Val dAurelle Paul Lamarque, Dept Pathol, F-34000 Montpellier, FranceInst Genom Fonct, CNRS, UMR 5203, F-34000 Montpellier, France
Bibeau, Frederic
;
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Escriou, Virginie
;
Crespy, Philippe
论文数: 0引用数: 0
h-index: 0
机构:
Inst Genom Fonct, CNRS, UMR 5203, F-34000 Montpellier, France
INSERM, U661, F-34000 Montpellier, France
Univ Montpellier I, UMR 5203, F-34000 Montpellier, France
Univ Montpellier 2, UMR 5203, F-34000 Montpellier, FranceInst Genom Fonct, CNRS, UMR 5203, F-34000 Montpellier, France
Crespy, Philippe
;
Journot, Laurent
论文数: 0引用数: 0
h-index: 0
机构:
Inst Genom Fonct, CNRS, UMR 5203, F-34000 Montpellier, France
INSERM, U661, F-34000 Montpellier, France
Univ Montpellier I, UMR 5203, F-34000 Montpellier, France
Univ Montpellier 2, UMR 5203, F-34000 Montpellier, France
Montpellier GenomiX, Inst Genom Fonct, F-34000 Montpellier, FranceInst Genom Fonct, CNRS, UMR 5203, F-34000 Montpellier, France
Journot, Laurent
;
Hollande, Frederic
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h-index: 0
机构:
Inst Genom Fonct, CNRS, UMR 5203, F-34000 Montpellier, France
INSERM, U661, F-34000 Montpellier, France
Univ Montpellier I, UMR 5203, F-34000 Montpellier, France
Univ Montpellier 2, UMR 5203, F-34000 Montpellier, FranceInst Genom Fonct, CNRS, UMR 5203, F-34000 Montpellier, France
Hollande, Frederic
;
Joubert, Dominique
论文数: 0引用数: 0
h-index: 0
机构:
Inst Genom Fonct, CNRS, UMR 5203, F-34000 Montpellier, France
INSERM, U661, F-34000 Montpellier, France
Univ Montpellier I, UMR 5203, F-34000 Montpellier, France
Univ Montpellier 2, UMR 5203, F-34000 Montpellier, FranceInst Genom Fonct, CNRS, UMR 5203, F-34000 Montpellier, France
机构:
Univ Western Ontario, Dept Physiol & Pharmacol, London, ON, CanadaUniv Western Ontario, Dept Physiol & Pharmacol, London, ON, Canada
Alemayehu, Mistre
;
Dragan, Magdalena
论文数: 0引用数: 0
h-index: 0
机构:
Univ Western Ontario, Dept Physiol & Pharmacol, London, ON, CanadaUniv Western Ontario, Dept Physiol & Pharmacol, London, ON, Canada
Dragan, Magdalena
;
Pape, Cynthia
论文数: 0引用数: 0
h-index: 0
机构:
Univ Western Ontario, Dept Physiol & Pharmacol, London, ON, CanadaUniv Western Ontario, Dept Physiol & Pharmacol, London, ON, Canada
Pape, Cynthia
;
Siddiqui, Iram
论文数: 0引用数: 0
h-index: 0
机构:
Univ Western Ontario, Dept Pathol, London, ON, CanadaUniv Western Ontario, Dept Physiol & Pharmacol, London, ON, Canada
Siddiqui, Iram
;
Sacks, David B.
论文数: 0引用数: 0
h-index: 0
机构:
NIH, Dept Lab Med, Bethesda, MD 20892 USAUniv Western Ontario, Dept Physiol & Pharmacol, London, ON, Canada
Sacks, David B.
;
Di Guglielmo, Gianni M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Western Ontario, Dept Physiol & Pharmacol, London, ON, CanadaUniv Western Ontario, Dept Physiol & Pharmacol, London, ON, Canada
Di Guglielmo, Gianni M.
;
Babwah, Andy V.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Western Ontario, Dept Physiol & Pharmacol, London, ON, Canada
Univ Western Ontario, Childrens Hlth Res Inst, London, ON, Canada
Univ Western Ontario, Lawson Hlth Res Inst, London, ON, Canada
Univ Western Ontario, Dept Obstet & Gynecol, London, ON, CanadaUniv Western Ontario, Dept Physiol & Pharmacol, London, ON, Canada
Babwah, Andy V.
;
Bhattacharya, Moshmi
论文数: 0引用数: 0
h-index: 0
机构:
Univ Western Ontario, Dept Physiol & Pharmacol, London, ON, CanadaUniv Western Ontario, Dept Physiol & Pharmacol, London, ON, Canada
机构:
Inst Genom Fonct, CNRS, UMR 5203, F-34000 Montpellier, France
INSERM, U661, F-34000 Montpellier, France
Univ Montpellier I, UMR 5203, F-34000 Montpellier, France
Univ Montpellier 2, UMR 5203, F-34000 Montpellier, FranceInst Genom Fonct, CNRS, UMR 5203, F-34000 Montpellier, France
Bonnans, Caroline
;
Flaceliere, Maud
论文数: 0引用数: 0
h-index: 0
机构:
Inst Genom Fonct, CNRS, UMR 5203, F-34000 Montpellier, France
INSERM, U661, F-34000 Montpellier, France
Univ Montpellier I, UMR 5203, F-34000 Montpellier, France
Univ Montpellier 2, UMR 5203, F-34000 Montpellier, FranceInst Genom Fonct, CNRS, UMR 5203, F-34000 Montpellier, France
Flaceliere, Maud
;
Grillet, Fanny
论文数: 0引用数: 0
h-index: 0
机构:
Inst Genom Fonct, CNRS, UMR 5203, F-34000 Montpellier, France
INSERM, U661, F-34000 Montpellier, France
Univ Montpellier I, UMR 5203, F-34000 Montpellier, France
Univ Montpellier 2, UMR 5203, F-34000 Montpellier, FranceInst Genom Fonct, CNRS, UMR 5203, F-34000 Montpellier, France
Grillet, Fanny
;
Dantec, Christelle
论文数: 0引用数: 0
h-index: 0
机构:
Inst Genom Fonct, CNRS, UMR 5203, F-34000 Montpellier, France
INSERM, U661, F-34000 Montpellier, France
Univ Montpellier I, UMR 5203, F-34000 Montpellier, France
Univ Montpellier 2, UMR 5203, F-34000 Montpellier, France
Montpellier GenomiX, Inst Genom Fonct, F-34000 Montpellier, FranceInst Genom Fonct, CNRS, UMR 5203, F-34000 Montpellier, France
Dantec, Christelle
;
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Desvignes, Jean-Pierre
;
论文数: 引用数:
h-index:
机构:
Pannequin, Julie
;
Severac, Dany
论文数: 0引用数: 0
h-index: 0
机构:
Inst Genom Fonct, CNRS, UMR 5203, F-34000 Montpellier, France
INSERM, U661, F-34000 Montpellier, France
Univ Montpellier I, UMR 5203, F-34000 Montpellier, France
Univ Montpellier 2, UMR 5203, F-34000 Montpellier, France
Montpellier GenomiX, Inst Genom Fonct, F-34000 Montpellier, FranceInst Genom Fonct, CNRS, UMR 5203, F-34000 Montpellier, France
Severac, Dany
;
Dubois, Emeric
论文数: 0引用数: 0
h-index: 0
机构:
Inst Genom Fonct, CNRS, UMR 5203, F-34000 Montpellier, France
INSERM, U661, F-34000 Montpellier, France
Univ Montpellier I, UMR 5203, F-34000 Montpellier, France
Univ Montpellier 2, UMR 5203, F-34000 Montpellier, France
Montpellier GenomiX, Inst Genom Fonct, F-34000 Montpellier, FranceInst Genom Fonct, CNRS, UMR 5203, F-34000 Montpellier, France
Dubois, Emeric
;
Bibeau, Frederic
论文数: 0引用数: 0
h-index: 0
机构:
Ctr Reg Lutte Canc Val dAurelle Paul Lamarque, Dept Pathol, F-34000 Montpellier, FranceInst Genom Fonct, CNRS, UMR 5203, F-34000 Montpellier, France
Bibeau, Frederic
;
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机构:
Escriou, Virginie
;
Crespy, Philippe
论文数: 0引用数: 0
h-index: 0
机构:
Inst Genom Fonct, CNRS, UMR 5203, F-34000 Montpellier, France
INSERM, U661, F-34000 Montpellier, France
Univ Montpellier I, UMR 5203, F-34000 Montpellier, France
Univ Montpellier 2, UMR 5203, F-34000 Montpellier, FranceInst Genom Fonct, CNRS, UMR 5203, F-34000 Montpellier, France
Crespy, Philippe
;
Journot, Laurent
论文数: 0引用数: 0
h-index: 0
机构:
Inst Genom Fonct, CNRS, UMR 5203, F-34000 Montpellier, France
INSERM, U661, F-34000 Montpellier, France
Univ Montpellier I, UMR 5203, F-34000 Montpellier, France
Univ Montpellier 2, UMR 5203, F-34000 Montpellier, France
Montpellier GenomiX, Inst Genom Fonct, F-34000 Montpellier, FranceInst Genom Fonct, CNRS, UMR 5203, F-34000 Montpellier, France
Journot, Laurent
;
Hollande, Frederic
论文数: 0引用数: 0
h-index: 0
机构:
Inst Genom Fonct, CNRS, UMR 5203, F-34000 Montpellier, France
INSERM, U661, F-34000 Montpellier, France
Univ Montpellier I, UMR 5203, F-34000 Montpellier, France
Univ Montpellier 2, UMR 5203, F-34000 Montpellier, FranceInst Genom Fonct, CNRS, UMR 5203, F-34000 Montpellier, France
Hollande, Frederic
;
Joubert, Dominique
论文数: 0引用数: 0
h-index: 0
机构:
Inst Genom Fonct, CNRS, UMR 5203, F-34000 Montpellier, France
INSERM, U661, F-34000 Montpellier, France
Univ Montpellier I, UMR 5203, F-34000 Montpellier, France
Univ Montpellier 2, UMR 5203, F-34000 Montpellier, FranceInst Genom Fonct, CNRS, UMR 5203, F-34000 Montpellier, France