T-helper cells as new players in ANCA-associated vasculitides

被引：55

作者：

Abdulahad, Wayel H. ^{[1
]}

Lamprecht, Peter ^{[2
,3
]}

Kallenberg, Cees G. M. ^{[1
]}

机构：

[1] Univ Groningen, Univ Med Ctr Groningen, Dept Rheumatol & Clin Immunol, NL-9713 GZ Groningen, Netherlands

[2] Univ Lubeck, Dept Rheumatol, Vasculitis Ctr UKSH, D-23562 Lubeck, Germany

[3] Univ Lubeck, Clin Ctr Bad Bramstedt, D-23562 Lubeck, Germany

来源：

ARTHRITIS RESEARCH & THERAPY | 2011年 / 13卷 / 04期

关键词：

ANTINEUTROPHIL CYTOPLASMIC AUTOANTIBODIES; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; ANTIBODY-ASSOCIATED VASCULITIS; WEGENERS-GRANULOMATOSIS WG; CHURG-STRAUSS-SYNDROME; PERIPHERAL-BLOOD; DISEASE-ACTIVITY; TH17; CELLS; NEUTROPHIL RECRUITMENT; MONOCLONAL-ANTIBODY;

D O I：

10.1186/ar3362

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In anti-neutrophil cytoplasmic autoantibody-associated vasculitides (AAV), several observations support a key role of T-helper cells (CD4(+) T cells) in disease pathophysiology. An expanded population of effector memory CD4(+) T cells in AAV patients may contribute to tissue injury and disease progression. In addition, functional impairment of regulatory T cells (T-Regs) is reported in AAV patients. A fraction of T-Regs have the capacity to differentiate into Th17 cells in the context of a proinflammatory environment. Therefore, nonfunctionality of T-Regs described in AAV patients may be caused by their conversion into IL-17-producing cells that may contribute to granulomatous vasculitis. Further investigations directed at the plasticity of T-Regs in AAV patients are warranted.

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页数：9

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