Optogenetic tools for analyzing the neural circuits of behavior

被引：197
作者：
Bernstein, Jacob G.
Boyden, Edward S. [1 ]
机构：
[1] MIT, MIT Media Lab, Cambridge, MA 02139 USA
来源：
TRENDS IN COGNITIVE SCIENCES | 2011年 / 15卷 / 12期
基金：
美国国家科学基金会;
关键词：
LIGHT-INDUCED ACTIVATION; IN-VIVO CONTROL; REMOTE-CONTROL; MILLISECOND-TIMESCALE; PROTEIN INTERACTIONS; OPTICAL ACTIVATION; CYTOPLASMIC LOOP; DRIVEN PROTON; MOTOR CORTEX; ION CHANNELS;
D O I：
10.1016/j.tics.2011.10.003
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
In order to understand how the brain generates behaviors, it is important to be able to determine how neural circuits work together to perform computations. Because neural circuits are made of a great diversity of cell types, it is critical to be able to analyze how these different kinds of cell work together. In recent years, a toolbox of fully genetically encoded molecules has emerged that, when expressed in specific neurons, enables the electrical activity of the targeted neurons to be controlled in a temporally precise fashion by pulses of light. We describe this optogenetic toolbox, how it can be used to analyze neural circuits in the brain and how optogenetics is impacting the study of cognition.
引用
收藏
页码：592 / 600
页数：9
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