The transcriptional landscape of the mammalian genome

被引：2702

作者：

Carninci, P

Kasukawa, T

Katayama, S

Gough, J

Frith, MC

Maeda, N

Oyama, R

Ravasi, T

Lenhard, B

Wells, C

Kodzius, R

Shimokawa, K

Bajic, VB

Brenner, SE

Batalov, S

Forrest, ARR

Zavolan, M

Davis, MJ

Wilming, LG

Aidinis, V

Allen, JE

Ambesi-Impiombato, X

Apweiler, R

Aturaliya, RN

Bailey, TL

Bansal, M

Baxter, L

Beisel, KW

Bersano, T

Bono, H

Chalk, AM

Chiu, KP

Choudhary, V

Christoffels, A

Clutterbuck, DR

Crowe, ML

Dalla, E

Dalrymple, BP

de Bono, B

Della Gatta, G

di Bernardo, D

Down, T

Engstrom, P

Fagiolini, M

Faulkner, G

Fletcher, CF

Fukushima, T

Furuno, M

Futaki, S

Gariboldi, M

机构：

来源：

SCIENCE | 2005年 / 309卷 / 5740期

关键词：

D O I：

10.1126/science.1112014

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

This study describes comprehensive polling of transcription start and termination sites and analysis of previously unidentified full-length complementary DNAs derived from the mouse genome. We identify the 5' and 3' boundaries of 181,047 transcripts with extensive variation in transcripts arising from alternative promoter usage, splicing, and polyadenylation. There are 16,247 new mouse protein-coding transcripts, including 5154 encoding previously unidentified proteins. Genomic mapping of the transcriptome reveals transcriptional forests, with overlapping transcription on both strands, separated by deserts in which few transcripts are observed. The data provide a comprehensive platform for the comparative analysis of mammalian transcriptional regulation in differentiation and development.

引用

页码：1559 / 1563

页数：5

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