P-glycoprotein and multidrug resistance

被引：498

作者：

Gottesman, MM ^{[1
]}

Pastan, I ^{[1
]}

Ambudkar, SV ^{[1
]}

机构：

[1] NCI,NIH,DIV BASIC SCI,MOL BIOL LAB,BETHESDA,MD 20892

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1996年 / 6卷 / 05期

关键词：

D O I：

10.1016/S0959-437X(96)80091-8

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Although the phenomenon of simultaneous resistance to multiple cytotoxic drugs (multidrug resistance) in cancer cells has been discussed for more than two decades, and the human and mouse genes encoding an energy-dependent transporter (the multidrug transporter or P-glycoprotein) responsible for multidrug resistance were cloned 10 years ago, there is still considerable controversy about the mechanism of action of this efflux pump and its true biological function. This review summarizes the current research on the mechanism of action of the multidrug transporter, including the hydrophobic cleaner and altered partitioning models, the possible function of P-glycoprotein as a chloride and/or ATP channel, the role of phosphorylation in its function and fact and speculation about its physiological role.

引用

页码：610 / 617

页数：8

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